医学における生命現象・疾病発症の総合的・統合的メカニズム解明を目指し研究を進めています。

業績一覧

100.
Miyazaki H, Shiozaki A, Niisato N, MARUNAKA Y.
Physiological significance of hypotonicity-induced regulatory volume decrease: reduction in intracellular Cl concentration acting as an intracellular signaling.
Am J Physiol Renal Physiol 292:F1411-1417, 2007.

99.
Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, MARUNAKA Y.
Action of neltenexine on anion secretion in human airway epithelia.
Biochem Biophys Res Commun 356:1050-1055, 2007.

98.
Yamada T, Iwasaki Y, Nagata K, Fushiki S, Nakamura H, MARUNAKA Y, Yodoi J.
Thioredoxin-1 protects against hyperoxia-induced apoptosis in cells of the alveolar walls.
Pulm Pharmacol Ther 20:650-659, 2007.

97.
Yasuda M, Niisato N, Miyazaki H, Hama T, Dejima K, Hisa MARUNAKA Y.
Epithelial ion transport of human nasal polyp and paranasal sinus mucosa.
Am J Respir Cell Mol Biol 36:466-472, 2007.

96.
Nagata K, Iwasaki Y, Yamada T, Yuba T, Kono K, Hosogi S, Ohsugi S, Kuwahara H, MARUNAKA Y.
Overexpression of manganese superoxide dismutase by N-acetylcysteine in hyperoxic lung injury.
Respir Med 101:800-807, 2007.

95.
Yuba T, Nagata K, Yamada T, Osugi S, Kuwahara H, Iwasaki Y, Handa O, Naito Y, Fushiki S, Yoshikawa T, MARUNAKA Y.
A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice.
Respir Med 101:793-799, 2007.

94.
Ogami A, Miyazaki H, Niisato N, Sugimoto T, MARUNAKA Y.
UT-B1 urea transporter plays a noble role as active water transporter in C6 glial cells.
Biochem Biophys Res Commun 351:619-624, 2006.

93.
MARUNAKA Y, Niisato N.
Ion transport/Calcium channel
Encyclopedia of Respiratory Medicine (Elsevier) 459-466, 2006.

92.
Shiozaki A, Miyazaki H, Niisato N, Nakahari T, Iwasaki Y, Itoi H, Ueda Y, Yamagishi H, MARUNAKA Y.
Furosemide, a blocker of Na+/K+/2Cl cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state.
J Physiol Sci 56:401-406, 2006.

91.
Iwasaki Y, Ohsugi S, Natsuhara A, Tsubokura T, Harada H, Ueda M, Arimoto T, Hara H, Yamada T, Takesako T, Kohno K, Hosogi S, Nakanishi M, MARUNAKA Y, Nishimura T.
Phase I/II trial of biweekly docetaxel and cisplatin with concurrent thoracic radiation for stage III non-small-cell lung cancer.
Cancer Chemother Pharmacol 58:735-741, 2006.

90.
Hasegawa I, Niisato N, Iwasaki, MARUNAKA Y.
Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia.
Biochem Biophys Res Commun 343:475-482, 2006.

89.
Aoi W, Niisato N, Sawabe Y, Miyazaki H, MARUNAKA Y.
Aldosterone-induced abnormal regulation of ENaC and SGK1 in Dahl salt-sensitive rat.
Biochem Biophys Res Commun 341:376-381, 2006.

88.
Saad AH, Shimamoto C, Nakahari T, Fujiwara S, Katsu K, MARUNAKA Y.
cGMP modulation of ACh-stimulated exocytosis in guinea pig antral mucous cells.
Am J Physiol Gastrointest Liver Physiol 290:G1138-G1148, 2006

87.
Fujimoto S, Niisato N, Sugimoto T, MARUNAKA Y.
Quercetin and NPPB-induced diminution of aldosterone action on Na+ absorption and ENaC expression in renal epithelium.
Biochem Biophys Res Commun. 336: 401-407, 2005.

86.
Ueda-Nishimura T, Niisato N, Miyazaki H, Naito Y, Yoshida N, Yoshikawa T, Nishino H,
MARUNAKA Y.
Synergic action of insulin and genistein on Na+/K+/2Cl cotransporter in renal epithelium.
Biochem Biophys Res Commun 332:1042-1052, 2005.

85.
MARUNAKA Y, Niisato N, Miyazaki H.
New concept of spare receptors and effectors.
J Membr Biol 203:31-39, 2005.

84.
Taguchi N, Niisato N, Sawabe Y, Miyazaki H, Hirai Y, MARUNAKA Y
Benzamil, a blocker of epithelial Na+ channel-induced upregulation of artery oxygen pressure level in acute lung injury rabbit ventilated with high frequency oscillation.
Biochem Biophys Res Commun 327:915-919, 2005.

83.
Niisato N, Eaton DC, MARUNAKA Y
Involvement of cytosolic Cl in osmoregulation of alpha-ENaC gene expression.
Am J Physiol Renal Physiol 287:F932-F939, 2004.

82.
Aoi W. Niisato N, Miyazaki H, MARUNAKA Y
Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat
Biochem Biophys Res Commun 315:892-896, 2004.

81.
Niisato N, Nishino H, Nishio K, MARUNAKA Y.
Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl channel and Na+/K+/2Cl cotransporter in renal epithelial A6 cells.
Biochem Pharmacol 67:795-801, 2004.

80.
Ishikawa T, Jiang C, Stutts MJ, MARUNAKA Y, Rotin D.
Regulation of the epithelial Na+ channel by cytosolic ATP.
J Biol Chem 278:38276-38286, 2003.

79.
MARUNAKA Y, Niisato N.
H89, an inhibitor of protein kinase A (PKA), stimulates Na+ transport by translocating an epithelial Na+ channel (ENaC) in fetal rat alveolar type II epithelium
Biochem Pharmacol 66:1083-1089, 2003.

78.
Yoshida H, MARUNAKA Y, Nakahari T.
[Ca2+]i oscillations induced by high [K+]o in acetylcholine-stimulated rat submandibular acinar cells: regulation by depolarization, cAMP and pertussis toxin.
Exp Physiol 88:369-379, 2003.

77.
Hirose M, Martyn JA, Kuroda MARUNAKA Y, Tanaka Y.
Mechanism of suppression of insulin signalling with lignocaine.
Br J Pharmacol 136:76-80, 2002.

76.
MARUNAKA Y, Niisato N.
Effects of Ca2+ channel blockers on amiloride-sensitive Na+ permeable channels and Na+ transport in fetal rat alveolar type II epithelium.
Biochem Pharmacol 63:1547-1552, 2002.

75.
Niisato N, Nishio K, MARUNAKA Y.
Activation of CFTR Cl channel by tyrphostins via a protein tyrosine kinase-independent pathway in forskolin-stimulated renal epithelial A6 cells.
Life Sci 71:1199-1207, 2002.

74.
Tokuda S, Niisato N, Morisaki S, MARUNAKA Y.
Calmodulin-dependent regulation of hypotonicity-induced translocation of ENaC in renal epithelial A6 cells.
Biochem Biophys Res Commun 298:619-623, 2002.

73.
MARUNAKA Y, Niisato N
Ion transport in the lung alveolar epithelium.
Membrane 27:221-32, 2002

72.
Niisato N, MARUNAKA Y
Forskolin activation of apical Cl channel and Na+/K+/2Cl cotransporter via a PTK-dependent pathway in renal epithelium.
Biochem Biophys Res Commun. 285:880-884, 2001.

71.
MARUNAKA Y, Niisato N
The essential role of cytosolic Cl in Ca2+ regulation of an amiloride-sensitive channel in fetal rat pneumocyte.
J Membrane Biol 180:91-99, 2001

70.
Niisato N, MARUNAKA Y.
Blocking action of cytochalasin D on PKA stimulation of stretch-activated cation channel in renal epithelial A6 cells.
Biochem Pharmacol 61:761-765, 2001

69.
Niisato N, Van Driessche W, Liu M, MARUNAKA Y.
Involvement of protein tyrosine kinase in osmoregulation of Na+ transport and membrane capacitance in renal A6 cells.
J Membrane Biol 175:63-77, 2000.

68.
Niisato N, Post M, Van Driessche W, MARUNAKA Y.
Cell swelling activates p38 MAP kinase and JNK in renal epithelial A6 cells.
Biochem Biophys Res Commun 266:547-550, 1999.

67.
Niisato N, Ito MARUNAKA Y.
Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms.
Life Sciences 65:PL109-114, 1999.

66.
Niisato N, Ito MARUNAKA Y.
cAMP stimulates Na+ transport in rat fetal lung epithelium: involvement of a PTK- but not a PKA-dependent pathway.
Am J Physiol 277: L727-L736, 1999.

65.
Niisato N, MARUNAKA Y.
Activation of the Na+,K+-pump by hyposmolality through tyrosine kinase-dependent Cl conductance in renal epithelium.
J Physiol (London) 518:417-432, 1999.

64.
MARUNAKA Y, Niisato N, O’Brodovich H, Eaton DC.
Regulation of amiloride-sensitive Na+-permeable channels by beta2-adrenergic agonist, cytosolic Ca2+ and Cl in fetal rat alveolar epithelium.
J Physiol (London) 515:669-683, 1999.

63.
MARUNAKA Y, Niisato N, O’Brodovich H, Post M, Tanswell AK.
Roles of Ca2+ and protein tyrosine kinase in insulin action on cell volume via Na+ and K+ channels and Na+/K+/2Cl cotransporter in fetal rat alveolar type II pneumocyte.
J Membrane Biol 168:91-101 1999.

62.
Niisato N, Ito MARUNAKA Y.
Activation of Cl channel and Na+/K+/2Cl cotransporter by flavonoids; genistein, daidzein and apigenin.
Biochem Biophys Res Commun 254:368-371, 1999.

61.
MARUNAKA Y, Niisato N.
Catecholamine regulation of amiloride-sensitive Na+ transport in the fetal rat alveolar epithelium.
Current Topics in Membranes and Transport 47:255-278, 1999

60.
Ishikawa T, MARUNAKA Y, Rotin D.
Electrophysiological characterization of the rat epithelial Na+ channel (rENaC) expressed in MDCK cells: effects of Na+ and Ca2+.
J Gen Physiol 111:825-846, 1998.

59.
MARUNAKA Y, Niisato N, Shintani Y.
Protein phosphatase 2B-dependent pathway of insulin action on single Cl channel conductance in renal epithelium.
J Membrane Biol 161:235-245, 1998.

58.
Ding JW, Dickie J, O’Brodovich H, Shintani Y, Rafii B, MARUNAKA Y, Rotstein OD.
Inhibition of amiloride-sensitive sodium activity in distal lung epithelial cells by nitric oxide. Am J Physiol 274:L378-L387, 1998.

57
MARUNAKA Y, Niisato N, Shintani Y.
Insulin-regulation of single chloride channel conductance via protein phosphatase 2B-dependent pathway.
Jpn J Physiol (J Physiol Sci) 47:S63-64, 1997.

56.
Niisato N, MARUNAKA Y.
Hyposmolality-induced enhancement of ADH action on amiloride-sensitive Isc in renal epithelial A6 cells.
Jpn J Physiol (J Physiol Sci) 47:131-137, 1997.

55.
Niisato N, Nakahari T, Tanswell AK, MARUNAKA Y.
Beta2-agonist regulation of cell volume in fetal distal lung epithelium by cAMP-independent Ca2+ release from intracellular stores.
Can J Physiol Pharmacol 75:1030-1033, 1997.

54.
MARUNAKA Y, Shintani Y, Downey GP, Niisato N.
Activation of Na+-permeant cation channel by stretch and cAMP-dependent phosphorylation in renal epithelial A6 cells.
J Gen Physiol 110:327-336, 1997.

53.
Ito Y, Niisato N, O’Brodovich H, MARUNAKA Y.
The effect of brefeldin A on terbutaline-induced sodium absorption in fetal rat distal lung epithelium.
Pfluegers Arch (Eur J Physiol) 434:492-494, 1997.

52.
Niisato N, MARUNAKA Y.
Regulation of Cl transport by IBMX in renal A6 epithelium.
Pfluegers Arch (Eur J Physiol) 434:227-233, 1997

51.
Niisato N, MARUNAKA Y.
Cross talk of bumetanide-sensitive and HCO3-dependent transporters activated by IBMX in renal epithelial A6 cells.
J Membrane Biol 157:53-61, 1997

50.
Nakahari T, MARUNAKA Y.
Beta-agonist induced activation of Na+ absorption and KCl release in fetal distal lung epithelium.
Exp Physiol 82:521-536, 1997

49.
MARUNAKA Y.
Hormonal and Osmotic Regulation of NaCl Transport in Renal Distal Nephron Epithelium. Jpn J Physiol (J Physiol Sci) 47:499-511, 1997 .

48.
MARUNAKA Y.
Physiological requirement of aldosterone action on the Na+/K+ pump in ADH-stimulated Na+ absorption in renal epithelium.
Jpn J Physiol (J Physiol Sci) 46:357-61, 1996.

47.
Nakahari T, MARUNAKA Y.
ADH action on whole cell currents by cytosolic Ca2+-dependent pathways in aldosterone-treated A6 cells.
J Membrane Biol 154:35-44, 1996.

46.
MARUNAKA Y, Shintani Y, Sugimoto E., Niisato N.
Roles of tyrosine kinase in insulin action on cell volume of fetal rat type II pneumocyte.
Pfluegers Arch (Eur J Physiol) 432:571-573, 1996.

45.
Shintani MARUNAKA Y.
Regulation of chloride channel trafficking by cyclic AMP via protein kinase A-independent pathway in A6 renal epithelial cells.
Biochem Biophys Res Commun 223:234-239, 1996.

44.
MARUNAKA Y.
Amiloride-blockable Ca2+-activated Na+-permeant channels in the fetal distal lung epithelium.
Pfluegers Arch (Eur J Physiol) 431:748-756, 1996.

43.
Nakahari T, MARUNAKA Y.
The regulation of cell volume by beta2-adrenergic stimulation in rat fetal lung epithelial cells.
J Membrane Biol 151:91-100, 1996.

42.
Shintani MARUNAKA Y.
Regulation of single Cl channel conductance by insulin and tyrosine phosphatase.
Biochem Biophys Res Commun 218:142-147, 1996.

41.
MARUNAKA Y, Tohda H.
Benzamil-induced conductive state of insulin-stimulated, amiloride-blockable cation channel in fetal lung epithelium.
Jpn J Physiol (J Physiol Sci) 45:895-904, 1995.

40.
Nakahari T, MARUNAKA Y.
Regulation of whole cell currents by cytosolic cAMP, Ca2+ and Cl in rat fetal distal epithelium.
Am J Physiol 269:C156-C162, 1995.

39.
MARUNAKA Y, Doi Y, Nakahari T.
Bumetanide and bicarbonate increase short-circuit current in fetal lung epithelium.
Gen Pharmacol (Vascular Pharmacology) 26:1513-1517, 1995.

38.
Doi MARUNAKA Y.
Amiloride-sensitive and HCO3-dependent ion transport activated by aldosterone and vasotocin in A6 cells.
Am J Physiol 268:C762-C770, 1995.

37.
Doi MARUNAKA Y.
Antidiuretic hormone decreases the intracellular pH in distal nephron epithelium (A6) by inhibiting Na+/H+ exchange.
Gen Pharmacol (Vascular Pharmacology) 26:723-726, 1995.

36.
Nakahari T, MARUNAKA Y.
ADH-evoked [Cl]i-dependent transient in whole cell current of a distal nephron cell line (A6).
Am J Physiol 268:F64-F72, 1995.

35.
MARUNAKA Y, Tohda H.
Benzamil-induced conductive state of insulin-stimulated, amiloride-blockable cation channel in fetal lung epithelium.
Jpn J Physiol (J Physiol Sci) 45:895-904, 1995.

34.
Nakahari T, MARUNAKA Y.
Whole cell conductance regulated by cytosolic [Cl] and ADH-activated Cl channels in a distal nephron cell line (A6).
Jpn J Physiol (J Physiol Sci) 44:S295-S300, 1994.

33.
MARUNAKA Y, Nakahari T, Tohda H.
Cytosolic [Cl] regulates Na+ absorption in fetal alveolar epithelium? Roles of cAMP and Cl channels.
Jpn J Physiol (J Physiol Sci) 44:S281-S288, 1994.

32.
MARUNAKA Y, Tohda H.
The stimulatory action of vasopressin on single Cl channels in the apical membrane of distal nephron epithelium (A6).
Jpn J Physiol (J Physiol Sci) 44:S249-S254, 1994.

31.
MARUNAKA Y, Tohda H, Hagiwara N, Nakahari T.
Antidiuretic hormone-responding non-selective cation channel in distal nephron epithelium (A6).
Am J Physiol 266:C1513-C1522, 1994.

30.
Compeau CG, Rotstein OD, Tohda H, MARUNAKA Y, Rafii B, Slutsky AS, O’Brodovich H.
Endotoxin-stimulated alveolar macrophages impair lung epithelial sodium transport by an l-arginine dependent mechanism.
Am J Physiol 266:C1330-C1341, 1994.

29.
Tohda H, Foskett JK, O’Brodovich H, MARUNAKA Y.
Cl regulation of a Ca2+ activated non selective cation channel in beta agonist treated fetal distal lung epithelium.
Am J Physiol 266:C104-C109, 1994.

28.
MARUNAKA Y.
Modification of Ca2+-sensitivity of Ca2+-activated Cl channel by vasopressin and cholera toxin.
Jpn J Physiol (J Physiol Sci) 43:553-560, 1993.

27.
MARUNAKA Y and Tohda H.
Effects of vasopressin on single chloride channels in the apical membrane of distal nephron cells (A6).
Biochim Biophys Acta 1153:105-110, 1993.

26.
Wang X, Fedorko L, MARUNAKA Y, O’Brodovich H.
Whole cell Cl current in human peripheral airway epithelial cell line.
Can J Physiol Pharmacol 71:662-670, 1993.

25.
Wang X, MARUNAKA Y, Fedorko L, Dho S., Foskett JK, O’Brodovich H.
Activation of Cl currents by intracellular chloride in fibroblasts stably expressing human CFTR.
Can J Physiol Pharmacol 71:645-649, 1993.

24.
Ohara A, Murayama K, MARUNAKA Y.
Voltage dependence of Na+/K+ pump currents in two-cell-stage blastomeres of Cynops pyrrhogaster.
Comp Biochem Physiol 105A:421-426, 1993.

23.
Wang X, Kleyman T, Tohda H, MARUNAKA Y, O’Brodovich H.
5-(N-Ethyl-N-isopropyl)amiloride sensitive Na currents in intact fetal distal lung epithelial cells.
Can J Physiol Pharmacol 71:58-62, 1993.

22.
MARUNAKA Y, Tohda H, Hagiwara N, O’Brodovich H.
Cytosolic Ca2+-induced modulation of ion selectivity and amiloride sensitivity of a cation channel in fetal lung epithelium.
Biochem Biophys Res Commun 187:648-656, 1992.

21.
Hagiwara N, Tohda H, Doi Y, O’Brodovich H, MARUNAKA Y.
Effects of insulin and tyrosine kinase inhibitor on the short-circuit current in fetal alveolar epithelial cells of the lung.
Biochem Biophys Res Commun 187:802-808, 1992.

20.
MARUNAKA Y, Hagiwara N, Tohda H.
Insulin activates single amiloride-blockable Na channels in a distal nephron cell line (A6).
Am J Physiol 263:F392-F400, 1992.

19.
Eaton DC, MARUNAKA Y, Ling BN
Channels in Epithelial Tissue.
Membrane Transport in Biology 5:73-165, 1992

18.
Eaton DC, Ohara A, Ling BN, MARUNAKA Y, Duchatelle P, Kemendy AE, Kokko KE, Matsumoto P, Hinton CF.
Cellular regulation of amiloride-blockable sodium channels.
Biomed Res 12:S31-S35, 1991.

17.
MARUNAKA Y, Eaton DC.
Effects of vasopressin and cyclic AMP on single amiloride-blockable Na channels.
Am J Physiol 260:C1071-C1084, 1991.

16.
MARUNAKA Y, Ohara A, Matsumoto P, Eaton DC.
Cyclic GMP-activated channel activity in renal epithelial cells (A6).
Biochim Biophys Acta 1070:152-156, 1991.

15.
MARUNAKA Y.
The sensitivity of insulin-stimulated and basal Na efflux to ouabain in frog skeletal muscle cells.
Gen Pharmacol (Vascular Pharmacology) 22:949-954, 1991.

14.
MARUNAKA Y, Eaton DC.
The effects of insulin and phosphatase on a Ca2+-dependent Cl channel in a distal nephron cell line (A6).
J Gen Physiol 95:773-789, 1990.

13.
MARUNAKA Y, Eaton DC.
Chloride channels in the apical membrane of a distal nephron cell line (A6).
Am J Physiol 258:C352-C368, 1990.

12.
Ling BN, Kemendy AE, Kokko KE, Hinton CF, MARUNAKA Y, Eaton DC.
Regulation of the amiloride-blockable sodium channel from epithelial tissue.
Mol Cell Biochem 99:141-150, 1990.

11.
Eaton DC, MARUNAKA Y.
Channels, Noise and Impedance in Epithelia: Ion channel fluctuations: “noise” and single channel measurements.
Current Topics in Membranes and Transport 37:61-114, 1990

10.
MARUNAKA Y.
Relationship between ionic surroundings and insulin actions on glucose transport and Na,K-pump in muscles.
Comp. Biochem. Physiol. 89A:103-112, 1988.

9.
Ohara A, Doida Y, Murayama K, Imaizumi M, MARUNAKA Y, Kitasato H.
Na/K pump activity in the new membrane formed at first cleavage in Cynops pyrrhogaster eggs.
Developmental Biology 126:331-336, 1988.

8.
MARUNAKA Y.
Effects of internal Na and external K concentrations on Na/K coupling of Na,K-pump in frog skeletal muscle.
J Membrane Biol 101:19-31, 1988.

7.
MARUNAKA Y.
The effect of the internal Na concentration on the electrogenicity of the insulin-stimulated Na,K-pump in frog skeletal muscles.
Comp Biochem Physiol 86A:133-136, 1987.

6.
MARUNAKA Y, Murayama K, Kitasato H.
Diverse effects of insulin-induced hyperpolarization on 3-O-methyl-D-glucose (3-O-MG) transport in frog skeletal muscles.
Hormone and Metabolic Research 19:139-142, 1987.

5.
MARUNAKA Y, Kitasato H.
Insulin-induced changes in membrane potential and 3-O-methylglucose uptake at various external K concentrations in frog skeletal muscle.
Comp Biochem Physiol 86A:331-336, 1987.

4.
MARUNAKA Y.
Effects of external K concentration on the electrogenicity of the insulin-stimulated Na,K-pump in frog skeletal muscle.
J Membrane Biol 91:165-172, 1986.

3.
Kitasato H MARUNAKA Y.
Na-sensitive component of 3-O-methylglucose uptake in skeletal muscle.
J Membrane Biol 87:225-232, 1985.

2.
Kitasato H Sato S, MARUNAKA Y, Murayama K, Nishio K.
Apparent affinity changes induced by insulin of Na-K transport system in frog skeletal.
Jpn J Physiol (J Physiol Sci) 30:603-616, 1980.

1.
Kitasato H Sato S, MARUNAKA Y, Murayama K, Nishio K.
Effects of ouabain on Na efflux in high internal Na and insulin-preincubated muscles.
Jpn J Physiol (J Physiol Sci) 30:591-602, 1980.

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