Publication list of Prof. Yoshinori MARUNAKA
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Amitani H, Suzuki H, Kobayashi H, Murayama M, Sameshima-Uto N, Kuroda E, Kobayashi Y, Kawabe M, Amitani M, Inui A, MARUNAKA Y
Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty
Frontiers in Aging 5:1304217, 2024

The role of ion-transporting proteins in human disease
Int J Mol Sci 25:1726, 2024

Nakahari T, Suzuki C, Kawaguchi K, Hosogi H, Tanaka S, Asano S, Inui T, MARUNAKA Y
Ambroxol-enhanced Frequency and amplitude of beating cilia controlled by a voltage-gated Ca2+ channel, Cav1.2, via pHi increase and [Cl]i decrease in the lung airway epithelial cells of mice
Int J Mol Sci 24:16976, 2023

Physiological roles of chloride ions in bodily and cellular functions
J Physiol Sci 73:31, 2023

Minamibata A, Kono Y, Arimoto T, MARUNAKA Y, Takayama K.
Variability of serum CYFRA 21−1 and its susceptibility to clinical characteristics in individuals without cancer: a 4-year retrospective analysis
BMC Pulmonary Medicine 23:344, 2023

Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus
Frontiers in Nutrition 10:1175660, 2023

Molecular mechanisms of obesity-induced development of insulin resistance and promotion of amyloid-ß accumulation: dietary therapy using weak organic acids via improvement of lowered interstitial fluid pH
Biomolecules 13(5): 779, 2023

Kato M, Horiguchi G, Ueda T, Hongo F, Okihara K, MARUNAKA Y, Teramukai S, Ukimura O
A big data-based on prediction model for prostate cancer incidence in Japanese men
Scientific Reports 13(1): 6579, 2023

Saito D, Suzuki C, Tanaka S, Hosogi S, Kawaguchi K, Asano S, Okamoto S, Yasuda M, Hirano S, Inui T, MARUNAKA Y, Nakahari T
Ambroxol-enhanced ciliary beating via voltage-gated Ca2+ channels in mouse airway ciliary cells
Eur. J. Pharmacol. 941:175496, 2023

Yamanoi Y, Lei J, Takayama Y, Hosogi S, MARUNAKA Y, Tominaga, M
TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes
Communications Biology 6(1):88, 2023

Hosogi S, Kuwahara A, Kuwahara Y, Tanaka S, Shimamoto C, Tagawa N, Kato I, Yoshimoto K, Aoi W, Takata K, Miyazaki H, Niisato N, Tsubo Y, Yagi K, Nakahari T, MARUNAKA Y
Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus
Biomedical Research 44(1):17-29, 2023

Hirao T, Kim BG, Habuchi H, Kawaguchi K, Nakahari T, MARUNAKA Y, Asano S
Transforming growth factor-β1 and bone morphogenetic protein-2 inhibit differentiation into mature ependymal multiciliated cells
Biol Pharm Bull 46(1):111-122, 2023

Amiloride-sensitive distal nephron controls extracellular fluid volume: ENaC and aldosterone
Kidney and Dialysis. 93(5):690-694, 2022

Takahashi K, Kuwahara Y, Kato I, Asano S, Kozakai T, MARUNAKA Y, Kuwahara A
Secondary bile acid lithocholic acid attenuates neurally evoked ion transport in the rat distal colon
Biomedical Research 43(6): 223-239, 2022

Shinomoto S, Tsubo Y, MARUNAKA Y
Detection and categorization of severe cardiac disorders based solely on heart period measurements
Scientific Reports 12(1):17019, 2022

Ishida M, Matsuzaki K, Suzuki H, Suzuki, Y, Kawamura T, MARUNAKA Y, Iwami T.
Association between 3-year repetitive isolated hematuria and eGFR deterioration in an apparently healthy population: A retrospective cohort study.
Int J Environ Res Public Health 19:11466, 2022

Minamibata A, Kono Y, Arimoto T, MARUNAKA Y, Takayama K.
Age and smoking status affect serum cytokeratin 19 fragment levels in individuals without cancer
In Vivo 36:2297-2302, 2022

Saitoh D, Kawaguchi K, Asano S, Inui T, MARUNAKA Y, Nakahari T.
Enhancement of airway ciliary beating mediated via voltage-gated Ca2+ channels/α7-nicotinic receptors in mice.
Pflugers Arch 474(10):1091-1106, 2022

Kuriyama N, Koyama T, Ozaki E, Saito S, Ihara M, Matsui D, Watanabe I, Kondo M, MARUNAKA Y, Takada A, Akazawa K, Tomida S, Nagamitsu R, Miyatani F, Miyake M, Nakano E, Kobayashi D, Watanabe Y, Mizuno S, Maekawa M, Yoshida T, Nukaya Y, Mizuno T, Yamada K, Uehara R
Association between cerebral microbleeds and circulating levels of mid-regional pro-adrenomedullin
J Alzheimer’s Disease 88(2):731-741, 2022

Ikeuchi Y, Kawaguchi K, Kogiso H, Saito D, Ikeda R, Asano S, Inui T, MARUNAKA Y, Nakahari T
Hochu-ekki-to enhanced airway ciliary beating by an [Ca2+]i increase via TRPV4 in mice
Phytomedicine Plus 2:100243, 2022

Kawaguchi K, Nakayama S, Saito D, Kogiso H, Yasuoka K, MARUNAKA Y, Nakahari T, Asano S
Ezrin knockdown reduces procaterol-stimulated ciliary beating without morphological changes in mouse airway cilia
J Cell Science 135 (6): jcs259201, 2022

Ion Transport: Calcium Channels. In: Janes, S.M. (Ed.), Encyclopedia of Respiratory Medicine, vol. 1. Elsevier, Academic Press, pp. 646–653, 2022

Kuwahara Y, Takahashi K, Akai M, Kato I, Kozakai T, Asano S, Inui T, MARUNAKA Y, Kuwahara A
Minimum biological domain of xenin-25 required to induce anion secretion in the rat ileum
Peptides 147:17068, 2022

Zheng K, Zhang W, Ding F, Zhou C, Shi J, MARUNAKA Y, Zou X
Using Ensemble Refinement (ER) Method to Optimize Transfer Set of Near Infrared Spectra
Spectroscopy and Spectral Analysis 42(4): 1323-1328, 2022

MARUNAKA Y, Yagi K, Imagawa N, Kobayashi H, Murayama M, Minamibata A, Takanashi Y, Nakahari T
Possibility of venous serum Cl concentration ([Cl]s) as a marker for human metabolic status: Correlation of [Cl]s to age, fasting blood sugar (FBS) and glycated hemoglobin (HbA1c)
Int J Mol Sci 22:11111, 2021

Tanaka S, Ito S, Shimamoto C, Matsumura H, Inui T, MARUNAKA Y, Nakahari T
NO synthesis stimulated by arachidonic acid accumulation via PPARα in acetylcholine-stimulated gastric mucous cells
Experimental Physiology 106(9):1939-1949, 2021

Aoi W, Iwasa M, MARUNAKA Y
Metabolic functions of flavonoids: from human epidemiology to molecular mechanism
Neuropeptides 88:102163, 2021

Essential requirement of complex number for oscillatory phenomenon in intracellular trafficking process
Computational and Structural Biotechnology Journal 19:2990-3005, 2021

Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance
Biochemical Society Transactions 49(2):715-726, 2021

Shiozaki A., MARUNAKA Y, Otsuji E.
Roles of ion and water channels in the cell death and survival of upper gastrointestinal tract cancers
Frontiers in Cell and Developmental Biology 9:616933, 2021

Hosogi S, MARUNAKA Y, Ashihara E, Yamada T, Sumino A, Tanaka H, Puppulin L
Plasma membrane anchored nanosensor for quantifying endogenous production of H2O2 in living cells
Biosensors and Bioelectronics 179:113077, 2021

Zheng K, Feng T, Zhang W, Huang X, Li Z, Zhang D, Shi J, MARUNAKA Y, Zou X
Weight SPXYE (WSPXYE) and its application to transfer set selection in near infrared spectra
Spectroscopy and Spectral Analysis 41(3):984-989, 2021

Kuwahara Y, Kato I, Inui T, MARUNAKA Y, Kuwahara A.
The effect of Xenin25 on spontaneous circular muscle contractions of rat distal colon in vitro
Physiological Reports 9(4):14752, 2021

The acidic microenvironment: Is it a phenotype of all cancers? A focus on multiple myeloma and some analogies with diabetes mellitus
Cancers 12:3226, 2020

Kuwahara A, Matsuda K, Kuwahara Y, Asano S, Inui T, MARUNAKA Y.
Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system.
Biomed Res 41(5):199-216, 2020

Cytosolic Cl-regulated cell function and diseases
Kidney and Dialysis. 88(3):419-422, 2020

Yasuda M, Inui TA, Hirano S, Inui T, MARUNAKA Y, Nakahari T
Intracellular Cl regulation of ciliary beating in ciliated human nasal epithelial cells: frequency and distance of ciliary beating observed by high-speed video microscopy.
Int. J. Mol. Sci 21(11):E4052, 2020

Marunaka R, MARUNAKA Y
Interactive actions of aldosterone and insulin on epithelial Na+ channel trafficking
Int J Mol Sci 21(10):E3407, 2020

Wang LS, Simal‐Gandara J, Du M, Lu B, Quiles JL, Chen ZY, Hennig B, Wang M, Xiao H, Arcot J, Yue T, Zheng B, Zou X, MARUNAKA Y, Ai L, Bai W, Battino M, Giampieri F, Georgiev MI, Liao X, Guven EC, Ismail A, Jafari SM, Li C, Mocan A, Wang J, Sun C, Xu BB, Yin J, Zengin G, Delmas D, Daglia M, Campos MG, Chen F, Xiong YL, Tundis R, Nie S, Xiao J
Food Frontiers: An academically sponsored new journal
Food Frontiers 1(1):3-5, 2020

Kogiso H, Raveau M, Yamakawa K, Saito D, Ikeuchi Y, Okazaki T, Asano S, Inui T, MARUNAKA Y, Nakahari T
Airway ciliary beating affected by the Pcp4 dose-dependent [Ca2+]i in Down syndrome mice, Ts1Rhr
Int J Mol Sci 21:1947, 2020

Zhao C, Lin G, Wu D, Liu D, You L, Högger P, Simal-Gandara J, Wang M, Galberto J, da Costa M, MARUNAKA Y, Daglia M, Khan H, Filosa R, Wang S, Xiao J
The algal polysaccharide ulvan suppresses growth of hepatoma cells
Food Frontiers 1(1):83-101, 2020

MARUNAKA Y, Niisato N, Zou X, Xiao J, Nakahari T
Food intake targeting and improving acidity in diabetes and cancer
Food Frontiers 1(1):9-12, 2020

Aoi W, Zou X, Xiao J, MARUNAKA Y
Body Fluid pH Balance in Metabolic Health and Possible Benefits of Dietary Alkaline Foods
eFood 1(1):12-23, 2020

Zheng K, Feng T, Zhang W, Huang X, Li Z, Zhang D, Shi J, MARUNAKA Y, Zou X
Refining transfer set in calibration transfer of near infrared spectra by backward refinement of samples
Analytical Methods 12(11):1495-1503, 2020

Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
ANO9 regulated cell cycle in Human Esophageal Squamous Cell Carcinoma
Annals of Surgical Oncology 27(9):3218-3230, 2020

Fukuda T, Tanaka M, Yamazaki M, MARUNAKA Y, Fukui M
Standard medical nutrition therapy of 25kcal/kg ideal bodyweight/day often does not reach even resting energy expenditure for patients with type 2 diabetes
Journal of Diabetes Investigation 11(3):626-632, 2020

Inui TA, Yasuda M, Hirano S, Ikeuchi Y, Kogiso H, Inui T, MARUNAKA Y, Nakahari T
Enhancement of ciliary beat amplitude by carbocisteine in ciliated human nasal epithelial cells
Laryngoscope 130(5):E289-E297, 2020

Kudou M, Shiozaki A, Yamazato Y, Katsurahara K, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E.
The expression and role of TRPV2 in esophageal squamous cell carcinoma
Scientific Reports 9 (1):16055, 2019

Mieno H, MARUNAKA Y, Inaba T, Kojima K, Yoneda K, Nagata K, Sotozono C
pH balance and lactic acid increase in the vitreous body of diabetes mellitus patients
Experimental Eye Research 188:107789, 2019

Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
LRRC8A expression influences growth of esophageal squamous cell carcinoma
Am J Pathol 189(10):1973-1985, 2019

Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, MARUNAKA Y, Otsuji E
Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells
Int J Oncol 55(4):905-914, 2019

Inui TA, Murakami K, Yasuda M, Hirano S, Ikeuchi Y, Kogiso H, Hosogi S, Inui T, MARUNAKA Y, Nakahari T
Ciliary beating amplitude controlled by intracellular Cl and a high rate of CO2 production in ciliated human nasal epithelial cells
Pflügers Archiv – European Journal of Physiology 471(8):1127-1142, 2019

Kuwahara A, Kuwahara Y, Kato I, Kawaguchi K, Harata D, Asano S, Inui T, and Marunaka Y
Xenin-25 induces anion secretion by activating non-cholinergic secretomotor neurons in the rat ileum
Am J Physiol Gastrointest Liver Physiol 316(6):G785-G796, 2019

Pillai SR, Damaghi M, Marunaka Y, Spugnini EP, Fais S, Gillies RJ
Causes, consequences, and therapy of tumors acidosis
Cancer Metastasis Reviews 38(1-2):205-222, 2019

Gillies RJ, Pilot C, MARUNAKA Y, Fais S
Targeting acidity in cancer and diabetes
Biochimica et Biophysica Acta Reviews on Cancer 1871(2):273-280, 2019

Okada Y, Okada T, Sato-Numata K, Islam MR, Ando-Akatsuka Y, Numata T, Kubo M, Shimizu T, Kurbannazarova RS, MARUNAKA Y, Sabirov RZ
Cell Volume-Activated and -Related Anion Channels in Mammalian Cells: Their Biophysical, Molecular and Pharmacological Properties
Pharmacological Reviews 71(1):49-88, 2019

Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Matsumura H, Inui T, MARUNAKA Y, Nakahari T
Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl]i in mouse airway cilia
Pflügers Archiv – European Journal of Physiology 471:365-380, 2019

Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Ichikawa D, Otsuji E.
Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.
Gastric Cancer 22(3):473-485, 2019

Inui T, Yasuda M, Hirano S, Ikeuchi Y, Kogiso H, Inui T, MARUNAKA Y, Nakahari T. Daidzein-stimulated increase in the ciliary beating amplitude via an [Cl]i decrease in ciliated human nasal epithelial cells
Int J Mol Sci 19:3754, 2018

Puppulin L, Hosogi S, Sun H, Matsuo K, Inui T, Kumamoto Y, Suzaki T, Tanaka H, MARUNAKA Y
Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement
Nature Communications 9(1) 5278, 2018

Hosogi S, Ohsawa M, Kato I, Kuwahara A, Inui T, Inui A, MARUNAKA Y
Improvement of diabetes mellitus symptoms by intake of Ninjin’yoeito
Frontiers in Nutrition 5:112, 2018

KuremotoT, Kogiso H, Yasuda M, Inui T, Murakami K, Hirano S, Ikeuchi Y, Hosogi S, Inui T, MARUNAKA Y, Nakahari T.
Spontaneous oscillation of the ciliary beat frequency regulated by release of Ca2+ from intracellular stores in mouse nasal epithelia
Biochem Biophys Res Commun 507:211-216, 2018

The proposal of molecular mechanisms of weak organic acids intake-induced improvement of insulin resistance in diabetes mellitus via elevation of interstitial fluid pH
Int J Mol Sci 19(10):3244, 2018

Marunaka R, Taruno A, Yamamoto T, Kanamura N, MARUNAKA Y
Action of protein tyrosine kinase inhibitors on the hypotonicity-stimulated trafficking kinetics of epithelial Na+ channels (ENaC) in renal epithelial cells: Analysis using a mathematical model.
Cell Physiol Biochm 50:363-377, 2018

Yamazato Y, Shiozaki A, Ichikawa D, KosugaT, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma
Oncotarget 9(52):29957-29974, 2018

Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma
Oncotarget 9(40):25993-26006, 2018

Kobayashi T, Shiozaki A, Nako Y, Ichikawa D, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E.
Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma
Oncotarget 9(33):23237-23252, 2018

Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, MARUNAKA Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker l, Mitchell C, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK.
CALHM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes.
Neuron 98(3):547-561, 2018

Kuwahara A, Kuwahara Y, Inui T, MARUNAKA Y.
Regulation of ion transport in the intestine by free fatty acid receptor 2 and 3: possible involvement of the diffuse chemosensory system.
Int J Mol Sci. 19:735, 2018

Kogiso H, Ikeuchi Y, Sumiya M, Hosogi S, Tanaka S, Shimamoto C, Inui T, MARUNAKA Y, Nakahari T.
Seihai-to (TJ-90)-induced activation of airway ciliary beatings of mice: Ca2+ modulation of cAMP-Stimulated Ciliary Beatings via PDE1.
Int J Mol Sci. 19:658, 2018

Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Inui T, Nakahari T, MARUNAKA Y.
Measurement of [Cl]i unaffected by the cell volume change using MQAE-based two-photon microscopy in airway ciliary cells of mice.
J Physiol Sci. 68(2):191-199, 2018

Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi M, Cui W, Matsuno K, MARUNAKA Y, Itoh Y, Torok NJ, Yabe-Nishimura C.
The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.
Free Radic Biol Med 115:412-420, 2018

Kogiso H, Hosogi S, Ikeuchi Y, Tanaka S, Inui T, MARUNAKA Y, Nakahari T.
[Ca2+]i modulation of cAMP-stimulated ciliary beat frequency via PDE1 in airway ciliary cells of mice.
Experimental Physiology 103(3):381-390, 2018

Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, MARUNAKA Y, Otsuji E.
Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor.
J Gastroenterol 53(2):197-207, 2018

MARUNAKA Y, Niisato N, Miyazaki H, Nakajima K, Taruno A, Sun H, Marunaka R, Okui M, Yamamoto T, Kanamura N, Kogiso H, Ikeuchi Y, Kashio M, Hosogi S, Nakahari T
Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport
Current Med Chem 25:4876-4887, 2018

Nomura T, Taruno A, Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, MARUNAKA Y.
Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics
Scientific Reports 7(1):10512, 2017

The mechanistic links between insulin and cystic fibrosis transmembrane conductance regulator (CFTR) Cl channel
Int J Mol Sci 18(8): pii: E1767, 2017

Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi K, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, MARUNAKA Y, Otsuji E.
Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer
Oncotarget 8(60):101394-101405, 2017

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