医学における生命現象・疾病発症の総合的・統合的メカニズム解明を目指し研究を進めています。

学会発表

200.
Niisato N, MARUNAKA Y.
Regulatory mechanism of Cl secretion by flavonoid in human airway epithelial Calu-3 cells.
J Physiol Sci 60 (suppl-1):26, 2010

199.
Yamada T, Takemura Y, Niisato N, Mitsuyama E, Iwasaki MARUNAKA Y.
Effects of ambroxol derivatives on ion transport in human airway Calu-3 epithelial.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 491, 2009

198.
Sawabe Y, MARUNAKA Y, Nakahari T, Yoshida H.
Acetylcholine-stimulated exocytosis enhanced by indomethacin via PPAR-alpha stimulation.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 433, 2009

197.
Yasuda M, Niisato N, Miyazaki H, Hama T, Dejima K, Hisa MARUNAKA Y. Characterization of epithelial ion transport of human nasal polyp and paranasal sinus mucosa.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 401, 2009

196.
Maki M, Miyazaki H, Nakajima K, Niisato N, Morihara T, MARUNAKA Y, Kubo T.
Chloride ions accelate cell cycle via modulation of Rb and CDC2 in osteiblastic cells.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 301, 2009

195.
Tokuda S, Niisato N, Nakajima K, MARUNAKA Y.
Regulation of paracellular ion conductances by NaCl gradients and osmolality in renal epithelial cells.
ernational Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 299, 2009

194.
Tokuda S, Nakahari T, Hosoi H, MARUNAKA Y.
HCO3 dependent regulation of pHc and overacidification of induced by NH4+ pulse in rat lung alveolar type II cells.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 296, 2009

193.
Asano J, Niisato N, Yasuda M, Iwasaki Y, Hama T, Dejima K, Hisa MARUNAKA Y.
Quercetin stimulates NKCC via PTK-dependent mechanism in huan airway epithelium.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 295, 2009

192.
Yamada T, Niisato N, MARUNAKA Y.
Effects of chloride ion on epithelial sodium channels (ENaC) in arginine vaspressin (AVT)-stimulated renal epithelial cells.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 295, 2009

191.
Nakajima K, Niisato N, MARUNAKA Y.
The role of chloride ion in dynamics of microtubule.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 350, 2009

190.
Miyazaki H, Ohsawa R, Niisato N, MARUNAKA Y.
Intracellular chloride regulates the G1/S cell cycle checkpoint in human gastric cancer MKN28 cells.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 304, 2009

189.
Ohsawa R, Miyazaki H, Otsuji E, Niisato N, MARUNAKA Y.
Intracellular chloride-dependent mechanism of activation of stress-activated protein kinases in human gastric MKN28 cells.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 303, 2009

188.
Hiraoka K, Miyazaki H, Niisato N, MARUNAKA Y.
Intracellular chloride regulates cell proliferation of androgen-I dependent prostate cancer PC3 cell.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 303, 2009

187.
Hosogi S, Takemura Y, Miyazaki H, Niisato N, Iwasaki Y, MARUNAKA Y.
Sodium hydrogen exchanger isoform 1 (NHE-1)-dependent proliferation of gastric cancer cells.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 303, 2009

186.
Nagai T, Niisato N, MARUNAKA Y.
Modification of osmoregulated ENaC trafficking by aldosterone and proteasome inhibitor.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 295, 2009

185.
Niisato N, Ohta M, MARUNAKA Y.
MKP1-dependent ERK dephosphorylation stimulates Na+ reabsorption through beta- and gamma-ENaC expression in hypotonic stress.
The 36th the International Congress of Physiological Sciences.
J Physiol Sci 59 (suppl-1): 208, 2009

184.
Miyazaki H, Niisato N, MARUNAKA Y.
Physiological importance of regulatory volume decrease: reduction in intracellular Cl concentration acting as an intracellular signaling.
Biophysics 48 (suppl 1):S158, 2008

183.
Yamada T, Niisato N, MARUNAKA Y.
Effect of chloride ion on epithelial sodium channels (ENaC) in AVT-stimulated renal epithelial cells.
Biophysics 48 (suppl 1):S158, 2008

182.
Ohsawa R, Miyazaki H, Shiozaki A, Otsuji E, Niisato N, MARUNAKA Y.
Reduction of intracellular Cl concentration induces the G1/S cell cycle arrest through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells.
J Physiol Sci 58 (suppl):S207, 2008

181.
Miyazaki H, Ohsawa R, Shiozaki A, Niisato N, MARUNAKA Y.
Intracellular chloride regulates the G1/S cell cycle checkpoint in MKN28 human gastric cancer cells.
J Physiol Sci 58 (suppl):S207, 2008

180.
Hiraoka K, Miyazaki H, Miki T, Niisato N, MARUNAKA Y.
Cell proliferation of prostatic cancer cell, LNCaP, is biphasically regulated by androgens.
J Physiol Sci 58 (suppl):S207, 2008

179.
Nakajima K, Niisato N, MARUNAKA Y.
Molecular mechanism of degradation and turnover of NKCC1.
J Physiol Sci 58 (suppl):S205, 2008

178.
Taruno A, Niisato N, MARUNAKA Y.
Osmoregulation of renal Na+ reabsorption: nongenomic mechanism.
J Physiol Sci 58 (suppl):S204, 2008

177.
Niisato N, Taruno A, MARUNAKA Y.
p38 MAPK is involved in hypotonicity-induced beta- and gamma-ENaC expression in renal epithelial A6 cells.
J Physiol Sci 58(suppl):S204, 2008

176.
Taruno A, Niisato N, MARUNAKA Y.
Osmoregulation of renal Na+ reabsorption: genomic mechanism.
J Physiol Sci 58(suppl):S115, 2008

175.
Niisato N, Taruno A, MARUNAKA Y.
Modification of osmoregulated ENaC trafficking by aldosterone in renal epithelium.
J Physiol Sci 58(suppl):S115, 2008

174.
Yamada T, Niisato N, MARUNAKA Y.
Effect of chloride ion on AVT-stimulated sodium current in renal epithelial cells.
J Physiol Sci 58(suppl):S70, 2008

173.
Tokuda S, Niisato N, MARUNAKA Y.
The regulatory mechanism of paracellular ion conductance by the water movement.
J Physiol Sci 57(suppl): S224, 2007.

172.
Taruno A, Niisato N, MARUNAKA Y.
Hypotonic stress stimulates Na+ reabsorption through Ca2+/ calmodulin-dependent SGK1 induction in renal epithelial A6 cells.
J Physiol Sci 57(suppl): S121, 2007.

171.
Nakajima K, Miyazaki H, Niisato N, MARUNAKA Y.
Implication of chloride transporter, NKCC1, in neurite outgrowth.
J Physiol Sci 57(suppl): S121, 2007.

170.
Ogami A, Miyazaki H, Niisato N, Sugimoto T, MARUNAKA Y.
Active water transport by the urea transporter, UT-B1, in C6 glioma cells.
J Physiol Sci 57(suppl): S121, 2007.

169.
Niisato N, MARUNAKA Y.
Cytosolic Cl acts as a signal molecule in hypotonic stress by regulating tyrosine
phosphorylation state of src kinase.
J Physiol Sci 57 (suppl): S61, 2007.

168.
Takemura Y, Komatani N, Nakahari T, Iwasaki Y, MARUNAKA Y.
Regulation of ciliary beating in rat bronchiolar ciliary cells.
J Physiol Sci 57 (suppl): S55, 2007.

167.
Miyazaki H, Shiozaki A, Niisato N, MARUNAKA Y.
Cl-dependent regulatory mechanisms of proliferation of human gastric cancer cells via G0/G1 arrest.
J Physiol Sci 57 (suppl): S20, 2007.

166.
Taruno A, Niisato N, MARUNAKA Y.
Genomic effect of hypotonic stress on Na+ reabsorption through Ca2+/ calmodulin-dependent SGK1 induction in renal epithelial A6 cells.
FASEB J 21: 772. 3, 2007.

165.
Tokuda S, Niisato N, MARUNAKA Y.
Ion-selective modification of paracellular conductance by the water fluxes.
FASEB J 21: 605. 6, 2007.

164.
Taruno A, Niisato N, MARUNAKA Y.
Involvement of receptor tyrosine kinases in the regulation of hypotonicity-induced Na+ reabsorption in renal epithelial A6 cells.
Jpn J Physiol 55 (Suppl): S84, 2005.

163.
Miyazaki H, Niisato N, MARUNAKA Y.
Prolonged exposure to hypertonic media induce rebound cell swelling through stress-activated protein kinase (SAPK) family in C6 rat glia cells.
Jpn J Physiol 55 (Suppl): S77, 2005.

162.
Niisato N, MARUNAKA Y.
Src kinase-dependent osmoregulation of Na+ reabsorption in renal epithelial A6 cells.
Jpn J Physiol 55 (Suppl): S37, 2005.

161.
Fujimoto S, Niisato N, Miyazaki H, Nishida M, Sugimoto T, MARUNAKA Y.
The effect of flavonoids on aldosterone-induced ion transport in renal epithelial A6 cells.
J Am Soc Nephrol 15: 306A, 2004.

160.
Aoi W, Niisato N, Sawabe Y, Miyazaki H, MARUNAKA Y.
Regulation of ENaC expression by aldosterone in Dahl salt-sensitive rat.
Jpn J Physiol 54 (Suppl): 274(1P255), 2004.

159.
Yasuda M, Niisato N, Miyazaki H, Dejima K, Hisa MARUNAKA Y.
Electrophysiological properties of nasal polyp and paranasal sinus mucosa.
Jpn J Physiol 54 (Suppl): 87(1P087), 2004.

158.
Hasegawa I, Niisato N, Miyazaki H, Iwasaki MARUNAKA Y.
Effects of ambroxol on ion transport in human Calu-3 cells.
Jpn J Physiol 54 (Suppl): 86(1P086), 2004.

157.
Nishio K, Niisato N, MARUNAKA Y.
Additional effect of myricetin on cAMP- stimulated C1- secretion in renal epitheial A6 cells.
Jpn J Physiol 54 (Suppl): 85(1P085), 2004.

156.
Shiozaki A, Niisato N, Miyazaki H, Itoi H, Yamagishi H, MARUNAKA Y.
Control of cell proliferation and mitochondrial activity by regulators of chloride ion transport in renal epithelial A6 cells.
Jpn J Physiol 54(Suppl): 70(1P070), 2004.

155.
Miyazaki H, Niisato N, MARUNAKA Y.
Mechanisms of rebound cell swelling in C6 glia cells prolonged exposed to hypertonic medium.
Jpn J Physiol 54 (Suppl): 52(1P052), 2004.

154.
Fujimoto S, Niisato N, Miyazaki H, Nishida M, Sugimoto T, MARUNAKA Y.
The effects of flavonoids on aldosterone – induced ion transport in renal epithelial cells.
Jpn J Physiol 54 (Suppl): 22(1P022), 2004.

153.
Nishimura T, Niisato N, Miyazaki H, Naito Y, Yoshida N, Yoshikawa T, MARUNAKA Y. Insulin enhances the stimulatory action of genistein on C1- transport by modifying translocation of C1- channel and Na+/K+/2C1- cotransporter in renal epithelial A6 cells.
Jpn J Physiol 54 (Suppl): 21(1P021), 2004.

152.
Niisato N, MARUNAKA Y.
Sensing mechanism of osmolality by SHP-2.
Jpn J Physiol 54 (Suppl): S164 (S38-5), 2004.

151.
Tsuchiya Y, Niisato N, MARUNAKA Y.
The effect of ambroxol on Cl transport ion renal epithelial A6 cells.
Jpn J Physiol 53:S155, 2003.

150.
Niisato N, MARUNAKA Y.
Physiological role of RVD as a sensing mechanism for hypotonic shock in renal A6 cells.
Jpn J Physiol 53:S125, 2003.

149.
Tokuda S, Niisato N, Morisaki S, MARUNAKA Y.
Calmodulin-dependent osmoregulation of ENaC translocation in renal epithelial A6 cells.
Jpn. J. Physiol. 53:S147, 2003.

148.
Aoi W, Niisato N, MARUNAKA Y.
The effect of flavone on blood pressure and ENaC expression.
Jpn J Physiol 53:S188, 2003.

147.
Niisato N, Nishio K, MARUNAKA Y.
Tyrphostins activate CFTR Cl channel via a protein tyrosine kinase-independent pathway in cAMP-stimulated renal epithelial A6 cells.
Jpn J Physiol 53:S146, 2003.

146.
MARUNAKA Y, Niisato N.
The essential role of cytosolic Cl in a catecholamine-activated amiloride-sensitive nonselective cation (NSC) channel in fetal rat pneumocyte.
Jpn J Physiol 53:S146, 2003.

145.
Kitagawa M, Yamada Y, Niisato N, MARUNAKA Y.
NPPB-induced enhancement of insulin action on cAMP-stimulated Cl transport in renal epithelial A6 cells.
Jpn J Physiol 53:S148, 2003.

144.
Ueda T, Niisato N, Naito Y, Yoshida N, Yoshikawa T, Nishino H, MARUNAKA Y.
Insulin potentiates genistein-stimulated Cl transport in renal epithelial A6 cells.
Jpn J Physiol 53:S157, 2003.

143.
MARUNAKA Y, Imai M.
Roles of epithelial ion transport in homeostasis and adaptation.
Jpn J Physiol 53:S124, 2003.

142.
MARUNAKA Y, Niisato N.
Ca2+ regulation of amiloride-sensitive Na+ absorption in cAMP-activated fetal rat type II pneumocytes
Am J Resp Crit Care Med 167:A395, 2003

141.
Niisato N, Nishino H, MARUNAKA Y.
Concerted regulation of CFTR and Na/K/2Cl cotransporter by cAMP and flavones.
The Proceedings of the 79th Annual Meeting, 2002 March 28-30,
Jpn. J. Physiol. 52 (Suppl) 59, 2002.

140.
MARUNAKA Y, Niisato N.
Regulatory Mechanisms of Amiloride-sensitive Na+ transport in Fetal Alveolar Epithelium. The Proceedings of the 79th Annual Meeting, 2002 March 28-30,
Jpn. J. Physiol. 52 (Suppl) S47, 2002.

139.
MARUNAKA Y, Niisato N.
Transport in Fetal Rat Alveolar Type II Epithelium.
The Federation of the Asian and Oceanian Physiological Societies (FAOPS) 4th Scientific Congress, 2002 September 22-26; Kuala Lumpur, Malasia.

138.
MARUNAKA Y.
Insulin modulation of chloride channel conductance in renal epithelial cells.
Experimental Biology 2002, 2002 April 20-24; New Orleans, USA.

137.
MARUNAKA Y.
Ion Transport in Lung.
Clinical Pediatric Anesthesia 7: 79, 2001.

136.
Niisato N, MARUNAKA Y.
Osmoregulation of Na+ reabsorption in renal epithelium: involvement of p38 MAPK in ENaC gene expression.
Jpn J Physiol 51 (Suppl): S59, 2001.

135.
Niisato N, Ito Y, MARUNAKA Y.
cAMP stimulates sodium transport in rat fetal lung epithelium: involvement of a PTK- but not a PKA-dependent pathway.
FASEB J. 14:A338, 2000.

134.
MARUNAKA Y, Niisato N, Eaton DC.
Gating properties of amiloride-sensitive Na+-permeable channel in rat fetal type II cells.
FASEB J. 13:A68, 1999.

133.
Niisato N, MARUNAKA Y.
Osmotic regulation of the Na+/K+-pump through tyrosine kinase-dependent Cl conductance in renal epithelium.
FASEB J. 13:A397, 1999.

132.
Niisato N, Liu M, Van Driessche W, MARUNAKA Y.
The involvement of PTK in osmoregulation of Na+ transport in Renal epithelial A6 cells.
FASEB J. 12:A450, 1998.

131.
MARUNAKA Y, Niisato N, Ito Y, Tanswell AK, O’Brodovich H.
Catecholamine regulation of amiloride-sensitive Na+-permeant channels in the fetal distal lung epithelium (FDLE).
FASEB J. 12:A500, 1998.

130.
Ishikawa T, MARUNAKA Y, Rotin D.
Electrophysiological characterization of rENaC expressed in MDCK cells.
Symposium “The Physiology and Functional Diversity of Amiloride-Sensitive Na+ channels: A New Gene Superfamily”
American Physiological Society, Physiologists 40:A5, 1997.

129.
Niisato N, Liu M, Van Driessche W, MARUNAKA Y.
Osmoregulation of Na+ transport in renal epithelial A6 cells.
Symposium “The Physiology and Functional Diversity of Amiloride-Sensitive Na+ channels: A New Gene Superfamily”
American Physiological Society, Physiologists 40:A6, 1997.

128.
MARUNAKA Y.
Properties of amiloride-blockable Na+-permeable channel in fetal rat distal lung epithelium.
Symposium “The Physiology and Functional Diversity of Amiloride-Sensitive Na+ channels: A New Gene Superfamily”
American Physiological Society, Physiologists 40:A22, 1997.

127.
Niisato N, MARUNAKA Y.
The regulation of Cl transport of renal A6 cells by IBMX.
FASEB J. 10:A83, 1996.

126.
Shintani Y, MARUNAKA Y.
Role of tyrosine phosphatase in insulin-induced regulation of single Cl channel conductance in renal A6 epithelium.
FASEB J. 10:A78, 1996.

125.
Doi Y, MARUNAKA Y.
Amiloride-sensitive and HCO3-dependent short-circuit currents activated by aldosterone and vasotocin in A6 cells.
FASEB J. 9:A304, 1995.

124.
MARUNAKA Y, Sugimoto E, Shintani Y, Niisato N.
Isobutyl-methyl-xanthine (IBMX) stimulates short-circuit currents via an increase in [Ca2+]i due to Ca2+ influx through Ca2+ channels in a phosphorylation-dependent manner in A6 cells.
FASEB J. 9:A304, 1995.

123.
Sugimoto E, Shintani Y, Buch S and MARUNAKA Y.
Insulin activates bumetanide-sensitive Na+/K+/2Cl cotransporter via tyrosine kinase-dependent pathway in rat type II pneumocyte.
FASEB J. 9:A279, 1995.

122.
Tohda H, MARUNAKA Y.
Two types of amiloride-sensitive Na+-permeant channels in the fetal distal lung epithelium.
FASEB J. 9:A63, 1995.

121.
Nakahari T, MARUNAKA Y.
ADH-evoked [Cl]i-dependent transient increases in whole cell currents of a distal nephron cell line (A6).
FASEB J. 9:A63, 1995.

120.
Shintani Y, MARUNAKA Y.
Cytoskeletal regulation of stretch-activated nonselective cation (NSC) channel via cAMP-dependent phosphorylation in distal nephron epithelium (A6).
FASEB J. 9:A3, 1995.

119.
MARUNAKA Y, Shintani Y, Sugimoto E, Nakahari T.
Modification of Ca2+-sensitivity of Ca2+-activated Cl channel by vasopressin, cholera toxin and insulin.
Jpn. J. Pharmacol. 67:38P, 1995.

118.
MARUNAKA Y, Tohda H, Nakahari T.
Non-selective cation channel in distal nephron epithelium (A6).
FASEB J. 8:A343, 1994.

117.
Wang Z, Tohda H, MARUNAKA Y.
Insulin-induced modification of benzamil action on non-selective cation channel in the fetal lung epithelium.
FASEB J. 8:A341, 1994.

116.
Wang J, Tohda H, MARUNAKA Y.
Two types of amiloride-blockable cation channels in the alveolar epithelium of the fetal lung.
FASEB J. 8:A341, 1994.

115.
Shintani Y, Doi Y, MARUNAKA Y.
Vasotocin decreases intracellular pH in distal nephron epithelium (A6).
FASEB J. 8:A68, 1994.

114.
Nakahari T, MARUNAKA Y.
Cyclic AMP activated amiloride-blockable whole cell current depended on [Cl]i in fetal lung cell of the rat.
FASEB J. 8:A340 1994.

113.
Umegaki K, MARUNAKA Y.
Effects of vasopressin on single Cl channels in the apical membrane of distal nephron epithelium (A6).
FASEB J. 8:A340 1994.

112.
Doi Y, MARUNAKA Y.
Bumetanide-stimulation of short-circuit current in beta-agonist treated fetal distal lung epithelium.
FASEB J. 8:A345 1994.

111.
Tohda H, MARUNAKA Y.
Cl regulation of a Ca2+ activated non selective cation channel in ァ agonist treated fetal distal lung epithelium.
FASEB J. 8:A340, 1994.

110.
MARUNAKA Y, Umegaki K.
The relationship between the effects of aldosterone (ALDO) and antidiuretic hormone (ADH) on transepithelial sodium reabsorption in a distal nephron epithelial cell line (A6).
Jpn. J. Physiol. 44:S36 1994.

109.
Nakahari T, MARUNAKA Y.
Antidiuretic hormone-evoked [Cl]i-dependent transients in whole cell currents in a distal nephron cell line (A6).
Jpn. J. Physiol. 44:S34 1994.

108.
Tohda H, MARUNAKA Y.
Cl regulation of a Ca2+ activated non selective cation channel in beta agonist treated fetal distal lung epithelium (FDLE).
Jpn. J. Physiol. 44:S37 1994.

107.
MARUNAKA Y.
A model of spare receptors and their effectors.
Jpn. J. Physiol. 44:S58 1994.

106.
Tohda H, MARUNAKA Y.
Benzamil activates the insulin-stimulated, amiloride-blockable cation channel in fetal lung epithelium.
Jpn. J. Physiol. 44:S36, 1994.

105.
MARUNAKA Y, Tohda H.
Vasopressin increases apical membrane Cl conductance in distal nephron epithelium (A6) through two different mechanisms.
Jpn. J. Physiol. 44:S36, 1994.

104.
MARUNAKA Y, Tohda H, Hagiwara N.
Antidiuretic hormone-responding non-selective cation channel in distal nephron epithelium (A6).
Jpn. J. Physiol. 44:S37 1994.

103.
MARUNAKA Y, Doi Y, Nakahari T.
Bumetanide increases the amiloride-sensitive short-circuit current in ァ-agonist stimulated fetal distal lung epithelium (FDLE).
Jpn. J. Physiol. 44:S35 1994.

102.
Wang X, Tohda H, Souza P, MARUNAKA Y, O’Brodovich H.
Fetal lung epithelium (FLE) has Cl and Na+ currents at different gestational ages (GA).
FASEB J. 7:A351, 1993.

101.
O’Brodovich H, Wang X, Tohda H, MARUNAKA Y, Li C, Bear C.
Novobiocin forms cation permeable ion channels in rat fetal distal lung epithelium
FASEB J. 7:A354, 1993.

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