医学における生命現象・疾病発症の総合的・統合的メカニズム解明を目指し研究を進めています。

Publication list of Prof. Yoshinori MARUNAKA

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Publication list of Prof. Yoshinori MARUNAKA
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278.
Amitani H, Suzuki H, Kobayashi H, Murayama M, Sameshima-Uto N, Kuroda E, Kobayashi Y, Kawabe M, Amitani M, Inui A, MARUNAKA Y
Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin’yoeito (NYT) on pre-frailty
Frontiers in Aging 5:1304217, 2024

277.
MARUNAKA Y
The role of ion-transporting proteins in human disease
Int J Mol Sci 25:1726, 2024

276.
Nakahari T, Suzuki C, Kawaguchi K, Hosogi H, Tanaka S, Asano S, Inui T, MARUNAKA Y
Ambroxol-enhanced Frequency and amplitude of beating cilia controlled by a voltage-gated Ca2+ channel, Cav1.2, via pHi increase and [Cl]i decrease in the lung airway epithelial cells of mice
Int J Mol Sci 24:16976, 2023

275.
MARUNAKA Y
Physiological roles of chloride ions in bodily and cellular functions
J Physiol Sci 73:31, 2023

274.
Minamibata A, Kono Y, Arimoto T, MARUNAKA Y, Takayama K.
Variability of serum CYFRA 21−1 and its susceptibility to clinical characteristics in individuals without cancer: a 4-year retrospective analysis
BMC Pulmonary Medicine 23:344, 2023

273.
Niisato N, MARUNAKA Y
Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus
Frontiers in Nutrition 10:1175660, 2023

272.
MARUNAKA Y
Molecular mechanisms of obesity-induced development of insulin resistance and promotion of amyloid-ß accumulation: dietary therapy using weak organic acids via improvement of lowered interstitial fluid pH
Biomolecules 13(5): 779, 2023

271.
Kato M, Horiguchi G, Ueda T, Hongo F, Okihara K, MARUNAKA Y, Teramukai S, Ukimura O
A big data-based on prediction model for prostate cancer incidence in Japanese men
Scientific Reports 13(1): 6579, 2023

270.
Saito D, Suzuki C, Tanaka S, Hosogi S, Kawaguchi K, Asano S, Okamoto S, Yasuda M, Hirano S, Inui T, MARUNAKA Y, Nakahari T
Ambroxol-enhanced ciliary beating via voltage-gated Ca2+ channels in mouse airway ciliary cells
Eur. J. Pharmacol. 941:175496, 2023

269.
Yamanoi Y, Lei J, Takayama Y, Hosogi S, MARUNAKA Y, Tominaga, M
TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes
Communications Biology 6(1):88, 2023

268.
Hosogi S, Kuwahara A, Kuwahara Y, Tanaka S, Shimamoto C, Tagawa N, Kato I, Yoshimoto K, Aoi W, Takata K, Miyazaki H, Niisato N, Tsubo Y, Yagi K, Nakahari T, MARUNAKA Y
Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus
Biomedical Research 44(1):17-29, 2023

267.
Hirao T, Kim BG, Habuchi H, Kawaguchi K, Nakahari T, MARUNAKA Y, Asano S
Transforming growth factor-β1 and bone morphogenetic protein-2 inhibit differentiation into mature ependymal multiciliated cells
Biol Pharm Bull 46(1):111-122, 2023

266.
Niisato N, MARUNAKA Y
Amiloride-sensitive distal nephron controls extracellular fluid volume: ENaC and aldosterone
Kidney and Dialysis. 93(5):690-694, 2022

265.
Takahashi K, Kuwahara Y, Kato I, Asano S, Kozakai T, MARUNAKA Y, Kuwahara A
Secondary bile acid lithocholic acid attenuates neurally evoked ion transport in the rat distal colon
Biomedical Research 43(6): 223-239, 2022

264.
Shinomoto S, Tsubo Y, MARUNAKA Y
Detection and categorization of severe cardiac disorders based solely on heart period measurements
Scientific Reports 12(1):17019, 2022

263.
Ishida M, Matsuzaki K, Suzuki H, Suzuki, Y, Kawamura T, MARUNAKA Y, Iwami T.
Association between 3-year repetitive isolated hematuria and eGFR deterioration in an apparently healthy population: A retrospective cohort study.
Int J Environ Res Public Health 19:11466, 2022

262.
Minamibata A, Kono Y, Arimoto T, MARUNAKA Y, Takayama K.
Age and smoking status affect serum cytokeratin 19 fragment levels in individuals without cancer
In Vivo 36:2297-2302, 2022

261.
Saitoh D, Kawaguchi K, Asano S, Inui T, MARUNAKA Y, Nakahari T.
Enhancement of airway ciliary beating mediated via voltage-gated Ca2+ channels/α7-nicotinic receptors in mice.
Pflugers Arch 474(10):1091-1106, 2022

260.
Kuriyama N, Koyama T, Ozaki E, Saito S, Ihara M, Matsui D, Watanabe I, Kondo M, MARUNAKA Y, Takada A, Akazawa K, Tomida S, Nagamitsu R, Miyatani F, Miyake M, Nakano E, Kobayashi D, Watanabe Y, Mizuno S, Maekawa M, Yoshida T, Nukaya Y, Mizuno T, Yamada K, Uehara R
Association between cerebral microbleeds and circulating levels of mid-regional pro-adrenomedullin
J Alzheimer’s Disease 88(2):731-741, 2022

259.
Ikeuchi Y, Kawaguchi K, Kogiso H, Saito D, Ikeda R, Asano S, Inui T, MARUNAKA Y, Nakahari T
Hochu-ekki-to enhanced airway ciliary beating by an [Ca2+]i increase via TRPV4 in mice
Phytomedicine Plus 2:100243, 2022

258.
Kawaguchi K, Nakayama S, Saito D, Kogiso H, Yasuoka K, MARUNAKA Y, Nakahari T, Asano S
Ezrin knockdown reduces procaterol-stimulated ciliary beating without morphological changes in mouse airway cilia
J Cell Science 135 (6): jcs259201, 2022

257.
Niisato N, MARUNAKA Y
Ion Transport: Calcium Channels. In: Janes, S.M. (Ed.), Encyclopedia of Respiratory Medicine, vol. 1. Elsevier, Academic Press, pp. 646–653, 2022

256.
Kuwahara Y, Takahashi K, Akai M, Kato I, Kozakai T, Asano S, Inui T, MARUNAKA Y, Kuwahara A
Minimum biological domain of xenin-25 required to induce anion secretion in the rat ileum
Peptides 147:17068, 2022

255.
Zheng K, Zhang W, Ding F, Zhou C, Shi J, MARUNAKA Y, Zou X
Using Ensemble Refinement (ER) Method to Optimize Transfer Set of Near Infrared Spectra
Spectroscopy and Spectral Analysis 42(4): 1323-1328, 2022

254.
MARUNAKA Y, Yagi K, Imagawa N, Kobayashi H, Murayama M, Minamibata A, Takanashi Y, Nakahari T
Possibility of venous serum Cl concentration ([Cl]s) as a marker for human metabolic status: Correlation of [Cl]s to age, fasting blood sugar (FBS) and glycated hemoglobin (HbA1c)
Int J Mol Sci 22:11111, 2021

253.
Tanaka S, Ito S, Shimamoto C, Matsumura H, Inui T, MARUNAKA Y, Nakahari T
NO synthesis stimulated by arachidonic acid accumulation via PPARα in acetylcholine-stimulated gastric mucous cells
Experimental Physiology 106(9):1939-1949, 2021

252.
Aoi W, Iwasa M, MARUNAKA Y
Metabolic functions of flavonoids: from human epidemiology to molecular mechanism
Neuropeptides 88:102163, 2021

251.
MARUNAKA Y, Yagi K
Essential requirement of complex number for oscillatory phenomenon in intracellular trafficking process
Computational and Structural Biotechnology Journal 19:2990-3005, 2021

250.
MARUNAKA Y
Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance
Biochemical Society Transactions 49(2):715-726, 2021

249.
Shiozaki A., MARUNAKA Y, Otsuji E.
Roles of ion and water channels in the cell death and survival of upper gastrointestinal tract cancers
Frontiers in Cell and Developmental Biology 9:616933, 2021

248.
Hosogi S, MARUNAKA Y, Ashihara E, Yamada T, Sumino A, Tanaka H, Puppulin L
Plasma membrane anchored nanosensor for quantifying endogenous production of H2O2 in living cells
Biosensors and Bioelectronics 179:113077, 2021

247.
Zheng K, Feng T, Zhang W, Huang X, Li Z, Zhang D, Shi J, MARUNAKA Y, Zou X
Weight SPXYE (WSPXYE) and its application to transfer set selection in near infrared spectra
Spectroscopy and Spectral Analysis 41(3):984-989, 2021

246.
Kuwahara Y, Kato I, Inui T, MARUNAKA Y, Kuwahara A.
The effect of Xenin25 on spontaneous circular muscle contractions of rat distal colon in vitro
Physiological Reports 9(4):14752, 2021

245.
Fais S, MARUNAKA Y
The acidic microenvironment: Is it a phenotype of all cancers? A focus on multiple myeloma and some analogies with diabetes mellitus
Cancers 12:3226, 2020

244.
Kuwahara A, Matsuda K, Kuwahara Y, Asano S, Inui T, MARUNAKA Y.
Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system.
Biomed Res 41(5):199-216, 2020

243.
MARUNAKA Y
Cytosolic Cl-regulated cell function and diseases
Kidney and Dialysis. 88(3):419-422, 2020

242.
Yasuda M, Inui TA, Hirano S, Inui T, MARUNAKA Y, Nakahari T
Intracellular Cl regulation of ciliary beating in ciliated human nasal epithelial cells: frequency and distance of ciliary beating observed by high-speed video microscopy.
Int. J. Mol. Sci 21(11):E4052, 2020

241.
Marunaka R, MARUNAKA Y
Interactive actions of aldosterone and insulin on epithelial Na+ channel trafficking
Int J Mol Sci 21(10):E3407, 2020

240.
Wang LS, Simal‐Gandara J, Du M, Lu B, Quiles JL, Chen ZY, Hennig B, Wang M, Xiao H, Arcot J, Yue T, Zheng B, Zou X, MARUNAKA Y, Ai L, Bai W, Battino M, Giampieri F, Georgiev MI, Liao X, Guven EC, Ismail A, Jafari SM, Li C, Mocan A, Wang J, Sun C, Xu BB, Yin J, Zengin G, Delmas D, Daglia M, Campos MG, Chen F, Xiong YL, Tundis R, Nie S, Xiao J
Food Frontiers: An academically sponsored new journal
Food Frontiers 1(1):3-5, 2020

239.
Kogiso H, Raveau M, Yamakawa K, Saito D, Ikeuchi Y, Okazaki T, Asano S, Inui T, MARUNAKA Y, Nakahari T
Airway ciliary beating affected by the Pcp4 dose-dependent [Ca2+]i in Down syndrome mice, Ts1Rhr
Int J Mol Sci 21:1947, 2020

238.
Zhao C, Lin G, Wu D, Liu D, You L, Högger P, Simal-Gandara J, Wang M, Galberto J, da Costa M, MARUNAKA Y, Daglia M, Khan H, Filosa R, Wang S, Xiao J
The algal polysaccharide ulvan suppresses growth of hepatoma cells
Food Frontiers 1(1):83-101, 2020

237.
MARUNAKA Y, Niisato N, Zou X, Xiao J, Nakahari T
Food intake targeting and improving acidity in diabetes and cancer
Food Frontiers 1(1):9-12, 2020

236.
Aoi W, Zou X, Xiao J, MARUNAKA Y
Body Fluid pH Balance in Metabolic Health and Possible Benefits of Dietary Alkaline Foods
eFood 1(1):12-23, 2020

235.
Zheng K, Feng T, Zhang W, Huang X, Li Z, Zhang D, Shi J, MARUNAKA Y, Zou X
Refining transfer set in calibration transfer of near infrared spectra by backward refinement of samples
Analytical Methods 12(11):1495-1503, 2020

234.
Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
ANO9 regulated cell cycle in Human Esophageal Squamous Cell Carcinoma
Annals of Surgical Oncology 27(9):3218-3230, 2020

233.
Fukuda T, Tanaka M, Yamazaki M, MARUNAKA Y, Fukui M
Standard medical nutrition therapy of 25kcal/kg ideal bodyweight/day often does not reach even resting energy expenditure for patients with type 2 diabetes
Journal of Diabetes Investigation 11(3):626-632, 2020

232.
Inui TA, Yasuda M, Hirano S, Ikeuchi Y, Kogiso H, Inui T, MARUNAKA Y, Nakahari T
Enhancement of ciliary beat amplitude by carbocisteine in ciliated human nasal epithelial cells
Laryngoscope 130(5):E289-E297, 2020

231.
Kudou M, Shiozaki A, Yamazato Y, Katsurahara K, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E.
The expression and role of TRPV2 in esophageal squamous cell carcinoma
Scientific Reports 9 (1):16055, 2019

230.
Mieno H, MARUNAKA Y, Inaba T, Kojima K, Yoneda K, Nagata K, Sotozono C
pH balance and lactic acid increase in the vitreous body of diabetes mellitus patients
Experimental Eye Research 188:107789, 2019

229.
Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
LRRC8A expression influences growth of esophageal squamous cell carcinoma
Am J Pathol 189(10):1973-1985, 2019

228.
Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, MARUNAKA Y, Otsuji E
Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells
Int J Oncol 55(4):905-914, 2019

227.
Inui TA, Murakami K, Yasuda M, Hirano S, Ikeuchi Y, Kogiso H, Hosogi S, Inui T, MARUNAKA Y, Nakahari T
Ciliary beating amplitude controlled by intracellular Cl and a high rate of CO2 production in ciliated human nasal epithelial cells
Pflügers Archiv – European Journal of Physiology 471(8):1127-1142, 2019

226.
Kuwahara A, Kuwahara Y, Kato I, Kawaguchi K, Harata D, Asano S, Inui T, and Marunaka Y
Xenin-25 induces anion secretion by activating non-cholinergic secretomotor neurons in the rat ileum
Am J Physiol Gastrointest Liver Physiol 316(6):G785-G796, 2019

225.
Pillai SR, Damaghi M, Marunaka Y, Spugnini EP, Fais S, Gillies RJ
Causes, consequences, and therapy of tumors acidosis
Cancer Metastasis Reviews 38(1-2):205-222, 2019

224.
Gillies RJ, Pilot C, MARUNAKA Y, Fais S
Targeting acidity in cancer and diabetes
Biochimica et Biophysica Acta Reviews on Cancer 1871(2):273-280, 2019

223.
Okada Y, Okada T, Sato-Numata K, Islam MR, Ando-Akatsuka Y, Numata T, Kubo M, Shimizu T, Kurbannazarova RS, MARUNAKA Y, Sabirov RZ
Cell Volume-Activated and -Related Anion Channels in Mammalian Cells: Their Biophysical, Molecular and Pharmacological Properties
Pharmacological Reviews 71(1):49-88, 2019

222.
Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Matsumura H, Inui T, MARUNAKA Y, Nakahari T
Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl]i in mouse airway cilia
Pflügers Archiv – European Journal of Physiology 471:365-380, 2019

221.
Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Ichikawa D, Otsuji E.
Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.
Gastric Cancer 22(3):473-485, 2019

220.
Inui T, Yasuda M, Hirano S, Ikeuchi Y, Kogiso H, Inui T, MARUNAKA Y, Nakahari T. Daidzein-stimulated increase in the ciliary beating amplitude via an [Cl]i decrease in ciliated human nasal epithelial cells
Int J Mol Sci 19:3754, 2018

219.
Puppulin L, Hosogi S, Sun H, Matsuo K, Inui T, Kumamoto Y, Suzaki T, Tanaka H, MARUNAKA Y
Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement
Nature Communications 9(1) 5278, 2018

218.
Hosogi S, Ohsawa M, Kato I, Kuwahara A, Inui T, Inui A, MARUNAKA Y
Improvement of diabetes mellitus symptoms by intake of Ninjin’yoeito
Frontiers in Nutrition 5:112, 2018

217.
KuremotoT, Kogiso H, Yasuda M, Inui T, Murakami K, Hirano S, Ikeuchi Y, Hosogi S, Inui T, MARUNAKA Y, Nakahari T.
Spontaneous oscillation of the ciliary beat frequency regulated by release of Ca2+ from intracellular stores in mouse nasal epithelia
Biochem Biophys Res Commun 507:211-216, 2018

216.
MARUNAKA Y
The proposal of molecular mechanisms of weak organic acids intake-induced improvement of insulin resistance in diabetes mellitus via elevation of interstitial fluid pH
Int J Mol Sci 19(10):3244, 2018

215.
Marunaka R, Taruno A, Yamamoto T, Kanamura N, MARUNAKA Y
Action of protein tyrosine kinase inhibitors on the hypotonicity-stimulated trafficking kinetics of epithelial Na+ channels (ENaC) in renal epithelial cells: Analysis using a mathematical model.
Cell Physiol Biochm 50:363-377, 2018

214.
Yamazato Y, Shiozaki A, Ichikawa D, KosugaT, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma
Oncotarget 9(52):29957-29974, 2018

213.
Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma
Oncotarget 9(40):25993-26006, 2018

212.
Kobayashi T, Shiozaki A, Nako Y, Ichikawa D, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E.
Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma
Oncotarget 9(33):23237-23252, 2018

211.
Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, MARUNAKA Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker l, Mitchell C, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK.
CALHM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes.
Neuron 98(3):547-561, 2018

210.
Kuwahara A, Kuwahara Y, Inui T, MARUNAKA Y.
Regulation of ion transport in the intestine by free fatty acid receptor 2 and 3: possible involvement of the diffuse chemosensory system.
Int J Mol Sci. 19:735, 2018

209.
Kogiso H, Ikeuchi Y, Sumiya M, Hosogi S, Tanaka S, Shimamoto C, Inui T, MARUNAKA Y, Nakahari T.
Seihai-to (TJ-90)-induced activation of airway ciliary beatings of mice: Ca2+ modulation of cAMP-Stimulated Ciliary Beatings via PDE1.
Int J Mol Sci. 19:658, 2018

208.
Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Inui T, Nakahari T, MARUNAKA Y.
Measurement of [Cl]i unaffected by the cell volume change using MQAE-based two-photon microscopy in airway ciliary cells of mice.
J Physiol Sci. 68(2):191-199, 2018

207.
Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi M, Cui W, Matsuno K, MARUNAKA Y, Itoh Y, Torok NJ, Yabe-Nishimura C.
The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.
Free Radic Biol Med 115:412-420, 2018

206.
Kogiso H, Hosogi S, Ikeuchi Y, Tanaka S, Inui T, MARUNAKA Y, Nakahari T.
[Ca2+]i modulation of cAMP-stimulated ciliary beat frequency via PDE1 in airway ciliary cells of mice.
Experimental Physiology 103(3):381-390, 2018

205.
Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, MARUNAKA Y, Otsuji E.
Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor.
J Gastroenterol 53(2):197-207, 2018

204.
MARUNAKA Y, Niisato N, Miyazaki H, Nakajima K, Taruno A, Sun H, Marunaka R, Okui M, Yamamoto T, Kanamura N, Kogiso H, Ikeuchi Y, Kashio M, Hosogi S, Nakahari T
Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport
Current Med Chem 25:4876-4887, 2018

203.
Nomura T, Taruno A, Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, MARUNAKA Y.
Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics
Scientific Reports 7(1):10512, 2017

202.
MARUNAKA Y.
The mechanistic links between insulin and cystic fibrosis transmembrane conductance regulator (CFTR) Cl channel
Int J Mol Sci 18(8): pii: E1767, 2017

201.
Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi K, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, MARUNAKA Y, Otsuji E.
Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer
Oncotarget 8(60):101394-101405, 2017

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