医学における生命現象・疾病発症の総合的・統合的メカニズム解明を目指し研究を進めています。

2001年〜2006年

原著 2006

1) Saad AH, Shimamoto C, Nakahari T, Fujiwara S, Katsu K, Marunaka Y. cGMP modulation of ACh-stimulated exocytosis in guinea pig antral mucous cells. Am J Physiol Gastrointest Liver Physiol 290:G1138-G1148, 2006

2) Aoi W, Niisato N, Sawabe Y, Miyazaki H, Marunaka Y.
Aldosterone-induced abnormal regulation of ENaC and SGK1 in Dahl salt-sensitive rat.
Biochem Biophys Res Commun. 341(2): 376-81, 2006.

3) Niisato N, Marunaka Y.
Molecular mechanism in biological transport in the kidney: Epithelial Na+ channel
Nippon Rinsho. 64 Suppl 2:119-22, 2006.

4) Hasegawa I, Niisato N, Iwasaki Y, Marunaka Y.
Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia.
Biochem Biophys Res Commun. 343:475-82, 2006.

5) Shiozaki A, Miyazaki H, Niisato N, Nakahari T, Iwasaki Y, Itoi H, Ueda Y, Yamagishi H, Marunaka Y.
Furosemide, a Blocker of Na+/K+/2Cl Cotransporter, Diminishes Proliferation of Poorly
Differentiated Human Gastric Cancer Cells by Affecting G0/G1 State
J Physiol Sci. 56:401-406, 2006.

6) Marunaka Y, Niisato N. Ion transport/Calcium channel. Encyclopedia of Respiratory Medicine (Elsevier) 459-466, 2006.

7) Ogami A, Miyazaki H, Niisato N, Sugimoto T, Marunaka Y.
UT-B1 urea transporter plays a noble role as active water transporter in C6 glial cells.
Biochem Biophys Res Commun. 351:619-24, 2006.

8) Iwasaki Y, Ohsugi S, Natsuhara A, Tsubokura T, Harada H, Ueda M, Arimoto T, Hara H, Yamada T, Takesako T, Kohno K, Hosogi S, Nakanishi M, Marunaka Y, Nishimura T. Phase I/II trial of biweekly docetaxel and cisplatin with concurrent thoracic radiation for stage III non-small-cell lung cancer. Cancer Chemother Pharmacol 58:735-741, 2006.

原著 2005

1) Taguchi N, Niisato N, Sawabe Y, Miyazaki H, Hirai Y, Marunaka Y.
Benzamil, a blocker of epithelial Na+ channel-induced upregulation of artery oxygen pressure level
in acute lung injury rabbit ventilated with high frequency oscillation.
Biochem Biophys Res Commun. 327: 915-919, 2005.

2) Marunaka Y, Niisato N, Miyazaki H.
New concenpt of spare receptors and effectors.
J Membr Biol. 203: 31-39, 2005.

3) Ueda-Nishimura T, Niisato N, Miyazaki H, Naito Y, Yoshida N, Yoshikawa T, Nishino H, Marunaka Y.
Synergic action of insulin and genistein on Na+/K+/2Cl cotransporter in renal epithelium.
Biochem Biophys Res Commun. 332: 1042-1052, 2005.

4) Fujimoto S, Niisato N, Sugimoto T, Marunaka Y.
Quercetin and NPPB?induced diminution of aldosterone action on Na+ absorption and ENaC
expression in renal epithelium.
Biochem Biophys Res Commun. 336: 401-7, 2005.

5) Adel H.Saad, Shoko Fujiwara, Chikako Shimamoto, Yoshinori Marunaka.
Enhancement of A Ch-stimulated exocytotic events by cGMP in guinea pig antral mucous cells.
Ulcer Research. 32: 168-171, 2005.

原著 2004

1) Niisato N, Eaton DC, Marunaka Y.
Involvement of cytosolic Cl in osmoregulation of alpha-ENaC gene expression.
Am J Physiol Renal Physiol. 287: F932-939, 2004.

2) Aoi W, Niisato N, Miyazaki H, Marunaka Y.
Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat.
Biochem Biophys Res Commun. 315: 892-896, 2004.

3) Niisato N, Nishino H, Nishio K, Marunaka Y.
Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance
regulator (CFTR) Cl channel and Na+/K+/2Cl cotransporter in renal epithelial A6 cells.
Biochem Pharmacol. 67:795-801, 2004.

4) Morita H, Ogino T, Fujiki N, Tanaka K, Gotoh TM, Seo Y, Takamata A, Nakamura S, Murakami M
Sequence of forebrain activation induced by intraventricular injection of hypertonic NaCl detected by
Mn2+ contrasted T1-weighted MRI,
Auton Neurosci. 113: 43-54, 2004.

5) Tomoyuki Ito, Toshiyuki Itoh, Takashi Hayano, Katsuya Yamauchi and Akira Takamata.
Plasma hyperosmolality augments peripheral vascular response to baroreceptor unloading during heat
stress,
Am J Physiol Regul Integr Comp Physiol. 289; 432-440, 2005

原著 2003

1) Marunaka Y, Niisato N.
H89, an inhibitor of protein kinase A (PKA), stimulates Na+ transport by translocating an epithelial Na+ channel (ENaC) in fetal rat alveolar type II epithelium.
Biochem Pharmacol. 66: 1083-1089, 2003.

2) Ishikawa T, Jiang C, Stutts MJ, Marunaka Y, Rotin D.
Regulation of the epithelial Na+ channel by cytosolic ATP.
J Biol Chem. 278: 38276-38286, 2003

3) Yoshida H, Marunaka Y, Nakahari T.
[Ca2+]i oscillations induced by high [K+]o in acetylcholinestimulated rat submandibular acinar cells: regulation by depolarization, cAMP and pertussis toxin.
Exp Physiol. 88: 369-379, 2003.

4) Ikoma K, Kusaka K, Takamiya H, Eliav U, Navon G, Seo Y.
Evaluation of collagen fiber maturation and ordering in regenerating tendons employing H-1 double
quantum filtered NMR spectroscopy.
J Orthopaed Res. 21: 149-156, 2003.

5) Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S.
Size-selective loosening of the blood-brain barrier in claudn-5-deficient mice.
J Cell Biol. 161: 653-660, 2003.

原著 2002

1) Morita H, Ogino T, Seo Y, Fujiki N, Tanaka K, Takamata A, Murakami M.
Detection of hypothalamic activation by manganese ion contrasted T1-weighted magnetic resonance imaging.
Neurosci Lett 326: 101-104, 2002

2) Shinar H, Seo Y, Ikoma K, Kusaka Y, Eliav U, Navon G.
Mapping the fiber orientation in articular cartilage at rest and under pressure studied by 2H double quantum filtered MRI.
Magn Reson Med. 48: 322-330, 2002.

3) Seo Y, Takamata A, Ogino T, Morita H, Nakamura S, Murakami M.
Water permeability of capillaries in the subfornical organ of rats determined by Gd-DTPA2- enhanced 1H magnetic resonance imaging.
J Physiol. 545: 217-228, 2002

4) Tokuda S, Niisato N, Morisaki S, Marunaka Y.
Calmodulin-dependent regulation of hypotonicityinduced translocation of ENaC in renal epithelial A6 cells.
Biochem Biophys Res Commun. 298: 619-623, 2002.

5) Niisato N, Nishio K, Marunaka Y.
Activation of CFTR Cl channel by tyrphostins via a protein tyrosine kinase-independent pathway in forskolin-stimulated renal epithelial A6 cells.
Life Sci. 71: 1199-1207, 2002.

6) Marunaka Y, Niisato N.
Effects of Ca2+ channel blockers on amiloride-sensitive Na+ permeable channels and Na+ transport in fetal rat alveolar type II epithelium.
Biochem Pharmacol. 63: 1547-1552, 2002.

7) Hirose M, Martyn JA, Kuroda Y, Marunaka Y, Tanaka Y.
Mechanism of suppression of insulin signalling with lignocaine.
Br J Pharmacol. 136:76-80, 2002.(麻酔学教室との共同)

原著 2001

1) Niisato N, Marunaka Y.
Blocking action of cytochalasin D on PKA stimulation of stretch-activated cation channel in renal epithelial A6 cells.
Biochem Pharmacol. 61: 761-765, 2001

2) Marunaka Y, Niisato N.
The essential role of cytosolic Cl in Ca2+ regulation of an amiloridesensitive channel in fetal rat pneumocyte.
J Membrane Biol. 180: 91-99, 2001

3) Niisato N, Marunaka Y.
Forskolin activation of apical Cl- channel and Na+/K+/2Cl cotransporter via a PTK-dependent pathway in renal epithelium.
Biochem Biophys Res Commun. 285: 880-884, 2001

4) Marunaka Y, Niisato N.
Osmoregulation of sodium transport in renal epithelial cells. Electrolyte Transport across Exocrine Epithelia Ed. by Dinudom A, Cook DI.
University of Sydney Press. 15-20, 2001.

5) Niisato N, Marunaka Y.
PTK-dependent regulation of cAMP-stimulated Cl transport in renal A6 cells. Electrolyte Transport across Exocrine Epithelia Ed. by Dinudom A, Cook DI.
University of Sydney Press. 141-143, 2001.

6) Sogami M, Era S, Murakami M, Seo Y, Watari H, Uyesaka N.
Application of the transition state theory to water transport across cell membrane.
Biochi Biophys Acta. 1511: 42-48, 2001.

7) Kusaka Y, Nakajima S, Uemura O, Aoshiba H, Seo Y, Hirasawa Y.
Intradiscal solid phase displacement as a determinant of the centripetal fluid shift in the loaded intervertebral disc.
Spine. 26: E174-E181, 2001.

8) Ikoma K, Takamiya H, Kusaka Y, Seo Y.
1H Double-quantum filtered MR imaging of joints tissues: “Bound water” specific imaging of tendons, ligaments and cartilage.
Magn Reson Imag. 19: 1287-1296, 2001.

9) Takamata A, Yoshida T, Nishida N, Morimoto T.
Relationship of osmotic inhibition in thermoregulatory responses and sweat sodium concentration in humans.
Am J Physiol Regul Integr Comp Physiol. 280: R623-R629, 2001.

10) Kasai T, Hirose M, Matsukawa T, Takamata A, Kimura M, Hosokawa T, Tanaka Y.
Preoperative risk factors of intraoperative hypothermia duirng open abdominal surgery.
Acta Anaesthesiol Scand. 45:1028-1031, 2001.

11) Takamata A, Seo Y, Ogino T, Tanaka K, Fujiki N, Morita H, Murakami M.
Effects of pCO2 on the CSF turnover rate in rats monitored by Gd-DTPA enhanced T1-weighted magnetic resonance imaging.
Jpn J Physiol. 51: 555-562, 2001.

12) Ito T, Takamata A, Yaegashi K, Itoh T, Yoshida T, Kawabata T, Kimura M, Morimoto T.
Role of blood volume in the age-associated decline in peak oxygen uptake in humans.
Jpn J Physiol. 51: 607-612, 2001.

お気軽にご連絡ください。 TEL 075-802-0131 内線 2322 受付時間 9:00 - 16:30 [ 土・日・祝日除く ]

PAGETOP
Copyright © 丸中良典研究室 All Rights Reserved.
Powered by WordPress & BizVektor Theme by Vektor,Inc. technology.