英文総説
1) Kuwahara A, Kuwahara Y, Inui T, MARUNAKA Y.
Regulation of ion transport in the intestine by free fatty acid receptor 2 and 3: possible involvement of the diffuse chemosensory system.
Int J Mol Sci. 19:735, 2018
2) MARUNAKA Y, Niisato N, Miyazaki H, Nakajima K, Taruno A, Sun H, Marunaka R, Okui M, Yamamoto T, Kanamura N, Kogiso H, Ikeuchi Y, Kashio M, Hosogi S, Nakahari T
Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport
Current Med Chem 25:4876-4887, 2018
3) MARUNAKA Y
The proposal of molecular mechanisms of weak organic acids intake-induced improvement of insulin resistance in diabetes mellitus via elevation of interstitial fluid pH
Int J Mol Sci 19(10):3244, 2018
英文原著
1) Inui T, Yasuda M, Hirano S, Ikeuchi Y, Kogiso H, Inui T, MARUNAKA Y, Nakahari T.
Daidzein-stimulated increase in the ciliary beating amplitude via an [Cl-]i decrease in ciliated human nasal epithelial cells
Int J Mol Sci 19:3754, 2018
2) Puppulin P, Hosogi S, Sun H, Matsuo K, Inui T, Kumamoto Y, Suzaki T, Tanaka H, MARUNAKA Y
Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement
Nature Communications 9(1) 5278, 2018
3) Hosogi S, Ohsawa M, Kato I, Kuwahara A, Inui T, Inui A, MARUNAKA Y
Improvement of diabetes mellitus symptoms by intake of Ninjin’yoeito
Frontiers in Nutrition 5:112, 2018
4) KuremotoT, Kogiso H, Yasuda M, Inui T, Murakami K, Hirano S, Ikeuchi Y, Hosogi S, Inui T, MARUNAKA Y, Nakahari T
Spontaneous oscillation of the ciliary beat frequency regulated by release of Ca2+ from intracellular stores in mouse nasal epithelia
Biochem Biophys Res Commun 507:211-216, 2018
5) Marunaka R, Taruno A, Yamamoto T, Kanamura N, MARUNAKA Y
Action of protein tyrosine kinase inhibitors on the hypotonicity-stimulated trafficking kinetics of epithelial Na+ channels (ENaC) in renal epithelial cells using a mathematical model.
Cell Physiol Biochem 50:363-377, 2018
6) Yamazato Y, Shiozaki A, Ichikawa D, KosugaT, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma
Oncotarget 9(52):29957-29974, 2018
7) Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E
Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma
Oncotarget 9(40):25993-26006, 2018
8) Kobayashi T, Shiozaki A, Nako Y, Ichikawa D, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, MARUNAKA Y, Otsuji E.
Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma
Oncotarget 9(33):23237-23252, 2018
9) Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, MARUNAKA Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker l, Mitchell C, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK.
CALHM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes.
Neuron 98(3):547-561, 2018
10) Kogiso H, Ikeuchi Y, Sumiya M, Hosogi S, Tanaka S, Shimamoto C, Inui T, MARUNAKA Y, Nakahari T.
Seihai-to (TJ-90)-induced activation of airway ciliary beatings of mice: Ca2+ modulation of cAMP-Stimulated Ciliary Beatings via PDE1.
Int J Mol Sci. 19:658, 2018
11) Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Inui T, Nakahari T, MARUNAKA Y.
Measurement of [Cl–]i unaffected by the cell volume change using MQAE-based two-photon microscopy in airway ciliary cells of mice.
J Physiol Sci. 68(2):191-199, 2018
12) Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi M, Cui W, Matsuno K, MARUNAKA Y, Itoh Y, Torok NJ, Yabe-Nishimura C.
The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.
Free Radic Biol Med 115:412-420, 2018
13)
Kogiso H, Hosogi S, Ikeuchi Y, Tanaka S, Inui T, MARUNAKA Y, Nakahari T.
[Ca2+]i modulation of cAMP-stimulated ciliary beat frequency via PDE1 in airway ciliary cells of mice.
Experimental Physiology 103(3):381-390, 2018
14) Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, MARUNAKA Y, Otsuji E.
Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor.
J Gastroenterol 53(2):197-207, 2018
国際学会 特別講演、招聘講演、基調講演、教育講演、シンポジウムなど
1) MARUNAKA Y
Plenary Lecture
Roles of ion circumstances in bodily and cellular functions: Physiological meanings of interstitial fluid pH and action of food on the interstitial fluid pH
The 3rd International Symposium on Phytochemicals in Medicine and Food
2018.07.24-30, Kunming, China
国内学会シンポジウム、ワークショップ、パネルディスカッションなど
1) Taruno A, Ma Z, Ohmoto M, Matsumoto I, Tordoff GM, Foskett JK, MARUNAKA Y
A CALHM1/CALHM3 heteromeric channel mediates purinergic neurotransmission of sweet, bitter, and umami tastes
Symposium on Sensible approaches for sensing channels: From physiology to pharmacology.
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S26, 2018
2) MARUNAKA Y
Invited Lecture
Effects of Ninjin’yoeito on insulin resistance via improvement of the interstitial fluid pH
Seminar on Possibility of the Chinese medicine in the super aged society
The 60th Annual Meeting of Japan Geriatircs Society. 2018.06.14-16; Kyoto, Japan.
Jpn. J. Geriatrics 55:S188, 2018
3) MARUNAKA Y
Invited Lecture
Epithelial Na+ channel (ENaC) trafficking process between the intracellular space and the apical membrane using mathematical analysis with a four–state model.
Symposium on “Molecular mechanisms of trafficking processes of ion channels and transporters between the plasma membrane and the intracellular space
The 40th Annual Meeting of The Membrane Society of Japan. 2018.05.08-09; Tokyo, Japan.
国際学会 一般講演（ポスター含む）
326.
Puppulin L, Hosogi S, Tanaka H, MARUNAKA Y
Highly localized pH sensing on the outer membrane of cells using
surface enhanced Raman spectroscopy
The 9th Congress of Federation of Asian and Oceanian Physiological Societies.
2019.03.28-31, Kobe, Japan
J Physiol Sci 69:S271, 2019
325.
Ikeuchi Y, Kogiso H, Tanaka S, Hosogi S, Nakahari T, Asano S, MARUNAKA Y
Airway ciliary beating activated by enhanced Ca2+ signal in Hochuekki-to (TJ-41) treated mice
The 9th Congress of Federation of Asian and Oceanian Physiological Societies. 2019.03.28-31, Kobe, Japan
J Physiol Sci 69:S268, 2019
324.
Kogiso H, Ikeuchi Y, Tanaka S, Hosogi S, Shimamoto C, Raveau M, Yamakawa K, Nakahari T, Asano S, MARUNAKA Y
Inhibition of the frequency of airway ciliary beating by PDE1
activation in Down syndrome mouse
The 9th Congress of Federation of Asian and Oceanian Physiological Societies. 2019.03.28-31, Kobe, Japan
J Physiol Sci 69:S266, 2019
323.
Marunaka R, MARUNAKA Y
Aldosterone action on epithelial Na+ channel trafficking under the
insulin-stimulated condition
The 9th Congress of Federation of Asian and Oceanian Physiological Societies. 2019.03.28-31, Kobe, Japan
J Physiol Sci 69:S252, 2019
322.
Kuwahara Y, Kato I, Kuwahara A, MARUNAKA Y
Neurogenic relaxation of Xenin on spontaneous circular muscle
contractions in rat distal colon
The 9th Congress of Federation of Asian and Oceanian Physiological Societies. 2019.03.28-31, Kobe, Japan
J Physiol Sci 69:S164, 2019
321.
Harata D, Asano J, Kuwahara A, Inui T, MARUNAKA Y
Secretory reflex pathway of SCFA in the rat distal colon
The 9th Congress of Federation of Asian and Oceanian Physiological Societies. 2019.03.28-31, Kobe, Japan
J Physiol Sci 69:S163, 2019
320.
Kuwahara A, Kuwahara Y, Kato I, Inui T, MARUNAKA Y
Secretory reflex pathway of Xenin-25 in the rat ileum
The 9th Congress of Federation of Asian and Oceanian Physiological Societies. 2019.03.28-31, Kobe, Japan
J Physiol Sci 69:S163, 2019
319.
Sun H, MARUNAKA Y, Asano S
Involvement of EP receptors in the regulation of Short circuit
current by prostaglandins in A6 cells
The 9th Congress of Federation of Asian and Oceanian Physiological Societies. 2019.03.28-31, Kobe, Japan
J Physiol Sci 69:S162, 2019
一般講演（ポスター含む）
1) Hino K. Ebisu G, Hosogi S, MARUNAKA Y
Improvement of blood glucose level in diabetic rats by intake of citrate
The 7th Asian Congress of Diabetes: The rise of nutrition and diabetes in Asia. 2018.07.06-08; Hong Kong; Cheung, G.; Siu, F., Eds. Hong Kong, 2018; p 170
2) Hosogi S, MARUNAKA Y, Nakahari T, Ikeuchi Y, Koiso H
Ambroxol-stimulated increases in CBA and CBF via pHi increase and [Cl-]i decrease in airway ciliary cells of mice.
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S171, 2018
3) Sun H, Taruno A, Nakajo K, Ono F, MARUNAKA Y
Regulation of CALHM1 channel gating and association with lipid microdomains by protein S-palmitoylation
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S169, 2018
4) Ikeuchi Y, Kogiso H, Tanaka S, Hosogi S, Nakahari T, MARUNAKA Y
Effect of carbocistein via Cl- on ciliary bend angle in mouse airway ciliary cells
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S140, 2018
5) Kogiso H, Ikeuchi Y, Hosogi S, Tanaka S, Nakahari T, MARUNAKA Y
Activation of ciliary beating by Sei-hai-to (TJ-90) in airway ciliary cell of mice
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S139, 2018
6) Miyazaki H, MARUNAKA Y
Effects of buffer components on pH dependency of recombinant human neprilysin activity
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S125, 2018
7) Marunaka R, Taruno A, MARUNAKA Y
Action of protein tyrosine kinase inhibitors on the trafficking kinetics of epithelial Na+ channels (ENaC) in renal epithelial cells: Analysis using a mathematical model
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S116, 2018
8) Kuwahara Y, Kuwahara A, MARUNAKA Y, Kato I
Xenin evokes anion secretion through non-cholinergic secretomotor neurons in rat ileum
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S115, 2018
9) Inui T, Murakami K, Yasuda M, Hirano S, Hosogi S, Nakahari T, MARUNAKA Y
A method to measure the amplitude of ciliary beating, CBD, in ciliated human nasal epithelial cells: enhancement of the amplitude by a [Cl–]i decrease.
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S115, 2018
10) Okui M, Sun H, Taruno A, MARUNAKA Y
Palmitoylation of CALHM3 positively controls activity of the CALHM1/3
channel
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S113, 2018
11)
Shiraishi M, Taruno A, MARUNAKA Y
CALHM and maxi-anion channels in mouse bladder urothelial cells
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S97, 2018
12) Puppulin L, Sun H, Tanaka H, MARUNAKA Y
High resolution imaging of proton extrusion in MNK-28 gastric cancer cells by Surface Enhanced Raman Spectroscopy.
The 95th Annual Meeting of the Physiological Society of Japan. 2018.3.28-30; Takamatsu.
J Physiol Sci 68: S91, 2018
原著
1) Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Inui T, Nakahari T, Marunaka Y.
Measurement of [Cl–]i unaffected by the cell volume change using MQAE-based two-photon microscopy in airway ciliary cells of mice.
J Physiol Sci. (in press)
2) Kogiso H, Ikeuchi Y, Sumiya M, Hosogi S, Tanaka S, Shimamoto C, Inui T, MARUNAKA Y, Nakahari T.
Seihai-to (TJ-90)-induced activation of airway ciliary beatings of mice: Ca2+ modulation of cAMP-Stimulated Ciliary Beatings via PDE1.
Int J Mol Sci. 19:658, 2018
科研費
1) 丸中良典（研究代表者） 基盤研究（B) （一般） （新規、2018年〜2021年)「食品成分による間質液pH制御を介した糖尿病・アルツハイマー型認知症発症予防法開発」
