原著
1) Tokuda S, Miyazaki H, Nakajima K, Yamada T, Marunaka Y.
Hydrostatic pressure regulates tight junctions, actin cytoskeleton and transcellular ion transport.
Biochem Biophys Res Commun. 390:1315-1321, 2009
2) Yamada T, Arimoto T, Koyama Y, Masui A, Tamiya N, Hosogi S, Hiramatu A, Nakanishi M, Kohno Y, Ueda M, Iwasaki Y, Marunaka Y.
Two cases of complex sleep apnea syndrome.
Nihon Kokyuki Gakkai Zasshi. 47:793-797, 2009 （呼吸器内科学教室との共同研究）
3) Hiramatsu A, Iwasaki Y, Koyama Y, Tamiya N, Hosogi S, Nakanishi M, Kohno Y, Ueda M, Arimoto T, Marunaka Y.
Phase II trial of weekly gemcitabine and split-dose cisplatin for advanced non-small-cell lung cancer.
Jpn J Clin Oncol. 39:779-783, 2009 （呼吸器内科学教室との共同研究）
4) Yamada T, Niisato N, Marunaka Y.
Effects of extracellular chloride ion on epithelial sodium channel (ENaC) in arginine vasotocin (AVT)-stimulated renal epithelial cells.
Biomed Res. 30:193-198, 2009
5) Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio K, Iwasaki Y, Marunaka Y.
Regulation of paracellular Na+ and Cl–conductances by hydrostatic pressure.
Cell Biol Int. 33:949-956, 2009
6) Maki M, Miyazaki H, Niisato N, Morihara T, Marunaka Y, Kubo T.
Blockers of K+/Cl– transporter/channels diminish proliferation of osteoblastic cells.
Biomed Res 30:137-140, 2009.
7) Yamada T, Takemura Y, Niisato N, Mitsuyama E, Iwasaki Y, Marunaka Y.
Action of N-acylated ambroxol derivatives on secretion of chloride ions in human airway epithelia.
Biochem Biophys Res Commun 380:586-590, 2009.
8) Asano J, Niisato N, Nakajima K, Miyazaki H, Yasuda M, Iwasaki Y, Hama T, Dejima K, Hisa Y, Marunaka Y.
Quercetin stimulates Na+/K+/2Cl– cotransport via PTK-dependent mechanisms in human airway epithelium.
Am J Respir Cell Mol Biol. 41:688-95, 2009
9) Sugino H, Futamura T, Mitsumoto Y, Maeda K, Marunaka Y.
Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice.
Prog Neuropsychopharmacol Biol Psychiatry 33:303-307, 2009.
10) Muroyama A, Inaka M, Matsushima H, Sugino H, Marunaka Y, Mitsumoto Y.
Enhanced susceptibility to MPTP neurotoxicity in magnesium-deficient C57BL/6N mice
Neurosci Res 63:72-75, 2009.
11) 中村知樹、楠崎克之、里中東彦、松原孝夫、松峯昭彦、内田淳正 原発性軟部肉腫に対するアクリジンオレンジ治療法の治療成績 臨整外 44：903－909、2009.
12) Nakamura T, Matsumine A, Kato H, Kusuzaki K, Nishimura K, Murata T, Shiraishi T, Oda Y, Tsuneyoshi M, Uchida A. Malignant melanoma with a rhabdoid phenotype exhibiting neumerous solid masses: A case report. Oncol Rep 21: 887-891, 2009.
13) Matsubara T, Kusuzaki K, Matsumine A, Murata H, Satonaka H, Shinntani K, Nakamura T, Hosoi H, Iehara T, Sugimoto T, Uchida A. A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabodomyosarcomas. Oncol Rep 21: 89-94, 2009.
14) Matsumine A, Kusuzaki K, Nakamura T, Nakazora S, Niimi R, Matsubara T, Uchida K, Murata T, Kudawara I, Ueda T, Naka N, Maeda M, Uchida A. Differentiation between neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis 1 evaluated by MRI. J Cancer Res Clin Oncol 135: 891-900, 2009
15) Araki K, Wakabayashi H, Shintani K, Morikawa J, Matsumine A, Kusuzaki K, Sudo A, Uchida A. Decorin suppresses bone metastasis in a breast cancer cell line. Oncology (Bazel) 77: 92-99 2009
16) Nakamura T, Matsumine A, Niimi R, Matsubara T, Kusuzaki K, Maeda M, Tagami T, Uchida A. Management of small pulmonary nodules in patients with sarcoma. Clin Exp Metastasis 26: 713-718, 2009
17) Akeda K, Nishimura A, Satonaka H, Shintani K, Kusuzaki K, Matsumine A, Kasai Y, Masuda K, Uchida A. Three-dimensional alginate spheroid culture system of murine osteosarcoma. Oncol Rep 22:997-1003, 2009.
国際学会
シンポジウム、ワークショップ、パネルディスカッション
1) Niisato N, Ohta M, Marunaka Y. ERK dephosphorylation by MKP-1 stimulates Na+ reabsorption through beta- and gamma-ENaC expression in hypotonic stress. Satellite Symposium of International Union of Physiological Sciences-2009, Epithelial Ion Transport in Health and Disease. July 23-25, 2009; Kyoto, Japan.
2) Miyazaki H, Ohsawa R, Niisato N, Marunaka Y. Intracellular chloride regulates the G1/S cell cycle checkpoint in human gastric cancer MKN28 cells. Satellite Symposium of International Union of Physiological Sciences-2009, Epithelial Ion Transport in Health and Disease. July 23-25, 2009; Kyoto, Japan.
3) Nakajima K, Niisato N, Marunaka Y. The role of chloride ion in dynamics of microtubule.
Satellite Symposium of International Union of Physiological Sciences-2009, Epithelial Ion Transport in Health and Disease. July 23-25, 2009; Kyoto, Japan.
4) Hosogi S, Miyazaki H, Marunaka Y. Inhibition of proliferation of gastric cancer cells by sodium hydrogen exchanger isoform 1(NHE-1). Satellite Symposium of International Union of Physiological Sciences-2009, Epithelial Ion Transport in Health and Disease. July 23-25, 2009; Kyoto, Japan.
5) Ohta M, Niisato N, Marunaka Y. p38 MAPK regulate ENaC-mediated Na+ transport y aldosterone in renal epithelial A6 cells. Satellite Symposium of International Union of Physiological Sciences-2009, Epithelial Ion Transport in Health and Disease. July 23-25, 2009; Kyoto, Japan.
6) Niisato N, Ohta M, Marunaka Y. Dephosphorylation of ERK by MKP-1 stimulates beta-and gamma-ENaC mRNA expression of renal A6 cells in hypotonic stress. 40th NIPS International symposium-International Joint symposium: PAT-CVR 2009. Augusut 3-6, 2009; Okazaki, Japan.
一般講演
1) Niisato N, Ohta M, Marunaka Y. MKP-1 dependent ERK dephosphorylation stimulates Na+ reabsorption through beta- and gamma-ENaC expression in hypotonic stress.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
2) Nagai T, Niisato N, Marunaka Y. Modification of osmoregulated ENaC trafficking by aldosterone and protease inhibitor.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
3) Hosogi S, Takemura Y, Miyazaki H, Niisato N, Iwasaki Y, Marunaka Y.
Sodium hydrogen exchanger isoform 1 (NHE-1)-dependent proliferation of gastric cancer cells.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
4) Hiraoka K, Miyazaki H, Niisato N, Marunaka Y.
Intracellular chloride regulates cell proliferation of androgen-independent prostate cancer PC3 cell.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
5) Ohsawa R, Miyazaki H, Otsuji E, Niisato N, Marunaka Y.
Intracellular chloride-dependent mechanism of activation of stress-activated protein kinases in human gastric cancer MKN28 cells.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
6) Miyazaki H, Ohsawa R, Niisato N, Marunaka Y.
Intracellular chloride regulates the G1/S cell cycle checkpoint in human gastric cancer MKN28 cells.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
7) Nakajima K, Niisato N, Marunaka Y.
The role of chloride ion in dynamics of microtubule.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
8) Yamada T, Niisato N, Marunaka Y.
Effects of chloride ion on epithelial sodium channels (ENaC) in arginine vasotocin (AVT)-stimulated renal epithelial cells.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
9) Asano J, Niisato N, Yasuda M, Iwasaki Y, Hama T, Dejima K, Hisa Y, Marunaka Y.
Quercetin stimulates NKCC via a PTK-dependent mechanism in human airway epithelium.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
10) Tokuda S, Nakahari T, Hosoi H, Marunaka Y.
HCO3– dependent regulation of pHc and overacidification induced by NH4+ pulse in rat lung alveolar type II cells.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
11) Tokuda S, Niisato N, Nakajima K, Marunaka Y.
Regulation of paracellular ion conductances by NaCl gradients and osmolality in renal epithelial cells.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
12) Maki M, Miyazaki H, Nakajima K, Niisato N, Morihara T, Marunaka Y, Kubo T.
Chloride ions accelerate cell cycle via modulation of Rb and Cdc2 in osteoblastic cells.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
13) Yasuda M, Niisato N, Miyazaki H, Hama T, Dejima K, Hisa Y, Marunaka Y.
Characterization of epithelial ion transport of human nasal polyp and paranasal sinus mucosa.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
14) Sawabe Y, Marunaka Y, Nakahari T, Yoshida H.
Acetylcholine-stimulated exocytosis enhanced by indomethacin via PPARa stimulation.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
15) Yamada T, Takemura Y, Niisato N, Mitsuyama E, Iwasaki Y, Marunaka Y.
Effects of ambroxol derivatives on ion transport in human airway Calu-3 epithelia.
36th International Congress of Physiological Sciences (IUPS2009).
July 27-August 1,2009; Kyoto, Japan.
16) Matsubara T, Kusuzaki K, Matsumine A, Nakamura T, Uchida A. Clinical outcome of minimal invasive surgery using acridine orange for musculoskeletal sarcomas around the forearm, comparing with conventional limb salvage surgery after wide resection. 15th ISOLS/MSTS Meeting, 2009 September 23-26; Boston, USA.
国内学会
特別講演、招聘講演、基調講演、教育講演など
1) 楠崎克之. 悪性骨軟部腫瘍に対するアクリジンオレンジを用いた光線力学的治療法の基礎と臨床． 第8回次世代医療システム産業化フォーラム. 2009 11.27；京都
2) 楠崎克之. アクリジンオレンジを用いた光線および放射線力学的治療法の手技―どの施設でもできる普及型の手技説明を含むー. 第1回アクリジンオレンジ治療研究会. 2009 11.28；京都
3) 松原孝夫、楠崎克之、松峯昭彦、中村知樹、内田淳正. 骨軟部腫瘍に対するAO therapyの臨床応用. 第1回アクリジンオレンジ治療研究会. 2009 11.28；京都
シンポジウム、ワークショップ、パネルディスカッションなど
1）新里直美，丸中良典．ケルセチンによる気道経上皮クロライド輸送制御機構．第8回肺サーファクタント分子病態研究会．2009年6月27日．札幌．
2) 濱口貴彦、松峯昭彦、中村知樹、若林弘樹、楠崎克之、内田淳正．当院における小児骨肉腫の治療成績 第112回中部日本整形外科・災害外科学会. 2009 4．9；京都市（主題 悪性骨軟部腫瘍に対する治療の工夫）
3) 松峯昭彦、中村知樹、新美塁、中空繁登、濱口貴彦、里中東彦、松原孝夫、楠崎克之、角永茂樹、橋本伸之、荒木信人、上田孝文、吉川秀樹、内田淳正. 悪性骨盤腫瘍に対する制御型人工関節の治療成績 （主題 骨盤腫瘍の治療の工夫）.第42回日本整形外科学会 骨・軟部腫瘍学術集会. 2009 7.16；横浜
一般講演
1）丸中良典，新里直美．ヒト気道上皮細胞におけるクロライドイオン分泌のフラボノイドによる制御機構．日本膜学会第31年会，2009年5月21日〜5月22日；東京．
2）丸中良典，新里直美．アルドステロンおよび浸透圧の上皮型ナトリウムチャネル細胞内局在修飾作用．日本膜学会第31年会，2009年5月21日〜5月22日；東京．
3）新里直美，西尾恭介，丸中良典． 低浸透圧刺激は、MKP1の発現制御によりENaCを介するNa+再吸収を亢進する．第52回日本腎臓学会学術総会，2009年6月3日〜5日；横浜.
4）丸中良典，新里直美．フラボノイドによる神経再生の試み．第12回研究報告会．2009年6月1日〜6月2日; 大阪．
5）安田誠，浅野純志，新里直美，宮崎裕明，中島謙一，岩崎吉伸，浜雄光，出島健司，久育男，丸中良典．ケルセチンはヒト気道上皮においてPTKが関与する経路を介しNa+/K+/2CL– cotransportを活性化する．第3回iPUC-II（Integrtated Pulonary Circulation Research-II）．2009年6月27日; 東京．
6）平岡健児，沖原宏治，浮村理，高羽夏樹，水谷陽一，河内明宏，宮崎裕明, 新里直美, 丸中良典, 三木恒治．クロライドイオン輸送体を分子標的とするアンドロゲン非依存性前立腺癌細胞増殖制御の試み．第97回日本泌尿器科学会総会．2009年4月16日〜19日；岡山．
7）丸中良典, 新里直美, 宮崎裕明, 中島謙一, 山田敏樹．プロテアーゼによるENaC寿命決定メカニズム． 第21回平成20年度助成研究発表会. 2009年7月21日; 東京.
8）中島謙一、新里直美、丸中良典．神経突起伸長におけるクロライドイオン輸送体NKCC1の役割—フラボノイドによる神経再生の試み—．生理研研究会「上皮組織における細胞外環境感受機構」2009年11月9日〜10日；岡崎．
9）太田麻利子、新里直美、丸中良典．アルドステロンによるNa+再吸収亢進はp38を介する．
生理研研究会「上皮組織における細胞外環境感受機構」2009年11月9日〜10日；岡崎．
学術集会でのプロシーディングス
1) Niisato N, Ohta M, Marunaka Y.
MKP-1 dependent ERK dephosphorylation stimulates Na+ reabsorption through beta- and gamma-ENaC expression in hypotonic stress.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 208, 2009
2) Nagai T, Niisato N, Marunaka Y.
Modification of osmoregulated ENaC trafficking by aldosterone and protease inhibitor.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 295, 2009
3) Hosogi S, Takemura Y, Miyazaki H, Niisato N, Iwasaki Y, Marunaka Y.
Sodium hydrogen exchanger isoform 1 (NHE-1)-dependent proliferation of gastric cancer cells.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 303, 2009
4) Hiraoka K, Miyazaki H, Niisato N, Marunaka Y.
Intracellular chloride regulates cell proliferation of androgen-independent prostate cancer PC3 cell.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 303, 2009
5) Ohsawa R, Miyazaki H, Otsuji E, Niisato N, Marunaka Y.
Intracellular chloride-dependent mechanism of activation of stress-activated protein kinases in human gastric cancer MKN28 cells.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 303, 2009
6) Miyazaki H, Ohsawa R, Niisato N, Marunaka Y.
Intracellular chloride regulates the G1/S cell cycle checkpoint in human gastric cancer MKN28 cells.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 304, 2009
7) Nakajima K, Niisato N, Marunaka Y.
The role of chloride ion in dynamics of microtubule.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 350, 2009
8) Yamada T, Niisato N, Marunaka Y.
Effects of chloride ion on epithelial sodium channels (ENaC) in arginine vasotocin (AVT)-stimulated renal epithelial cells.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 295, 2009
9) Asano J, Niisato N, Yasuda M, Iwasaki Y, Hama T, Dejima K, Hisa Y, Marunaka Y.
Quercetin stimulates NKCC via a PTK-dependent mechanism in human airway epithelium.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 295, 2009
10) Tokuda S, Nakahari T, Hosoi H, Marunaka Y.
HCO3– dependent regulation of pHc and overacidification induced by NH4+ pulse in rat lung alveolar type II cells.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 296, 2009
11) Tokuda S, Niisato N, Nakajima K, Marunaka Y.
Regulation of paracellular ion conductances by NaCl gradients and osmolality in renal epithelial cells.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 299, 2009
12) Maki M, Miyazaki H, Nakajima K, Niisato N, Morihara T, Marunaka Y, Kubo T.
Chloride ions accelerate cell cycle via modulation of Rb and Cdc2 in osteoblastic cells.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 301, 2009
13) Yasuda M, Niisato N, Miyazaki H, Hama T, Dejima K, Hisa Y, Marunaka Y. Characterization of epithelial ion transport of human nasal polyp and paranasal sinus mucosa.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 401, 2009
14) Sawabe Y, Marunaka Y, Nakahari T, Yoshida H.
Acetylcholine-stimulated exocytosis enhanced by indomethacin via PPARa stimulation.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 433, 2009
15) Yamada T, Takemura Y, Niisato N, Mitsuyama E, Iwasaki Y, Marunaka Y.
Effects of ambroxol derivatives on ion transport in human airway Calu-3 epithelia.
36th International Congress of Physiological Sciences (IUPS2009).
J Physiol Sci 59(suppl-1): 491, 2009
16) 新里直美，西尾恭介，丸中良典． 低浸透圧刺激は、MKP1の発現制御によりENaCを介するNa+再吸収を亢進する．日本腎臓学会誌51(3):318, 2009
科研費
1) 丸中良典（研究代表者）：基盤研究（B）（一般）（継続、H20～H23） 「プロテアーゼによるENaC細胞内局在制御メカニズムの解明」
2) 中島謙一（研究代表者）：若手B （継続、H20～H21）「クロライドイオンによる微小管の動態制御機構」
3) 樽野陽幸（研究代表者）：特別研究員奨励費（継続、H20～H22）「2型糖尿病における高血圧発症機構- 高血糖による腎でのSGK1発現とNa再吸収－」
4) 楠崎克之（分担研究者）：特定領域研究 （継続、H17～H21） 分担「骨軟部肉腫に対する個別化診断治療法の開発」
5) 楠崎克之（研究代表者）：基盤研究（B） （継続、H19～H21）「アクリジン色素とストロボ光を用いた骨・軟部腫瘍の同時・瞬間的診断治療戦略の開発」
6) 宮崎裕明（研究代表者）：若手研究（B）（新規、H21～H22）「WNKキナーゼによる細胞内クロライドセットポイント変化が細胞周期の進行を制御する」
7) 新里直美（分担研究者）：基盤研究（C）（一般）（継続、H20〜H22）「エンドトキシン起因性肺損傷におけるTLR遺伝子発現」
