和文総説
1) 樽野 陽幸, J. Kevin Foskett，丸中 良典.
明らかになってきたCALHMチャネルの構造と機能．
実験医学 32:3109-3114，2014
英文総説
1) Marunaka Y.
Roles of ionic environments in growth of human cancer cell and potentials of ion transporter blockers in cancer therapies
J Gastrointestinal and Digestive System 3:163, 2014
2) Aoi W, Marunaka Y.
The importance of regulation of body fluid pH in the development and progression of metabolic diseases
Advances in Medicine and Biology vol.77, pp. 177-189, 2014
Nova Publishers
3) Shiozaki A, Ishikawa D, Otsuji E, Marunaka Y
Cellular Physiological Approach for Treatment of Gastric Cancer
World Journal of Gastroenterology 20:11560-6, 2014 Sep
4) Marunaka Y
Importance of expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells
Respiratory Physiol Neurobiol 196:39-42, 2014
5）Marunaka Y
Characteristics and pharmacological regulation of epithelial Na+ channel (ENaC) and epithelial Na+ transport
J Pharmacol Sci 126:21-36 2014
6) Aoi W, MARUNAKA Y
Importance of pH homeostasis in metabolic health and diseases: crucial role of membrane proton transport
BioMed Res Int. 2014:598986, 2014
7) Shiozaki A, Ichikawa D, Fujiwara H, Otsuji E, MARUNAKA Y
Progress in Cellular Physiological Researches on Esophageal Cancer
Journal of Tumor 2:252-256, 2014
原著
1) Marunaka Y, Yoshimoto K, Aoi W, Hosogi S, Ikegaya H.
Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats
Molecular and Cellular Therapies 2:6, 2014
2) Hosogi S, Kusuzaki K, Inui T, Wang X, Marunaka Y.
Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell
J Cell Mol Med 18:1124-1133, 2014
3) Hayata H, Miyazaki H, Niisato N, Yokoyama N, MARUNAKA Y
Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance
Biochem Biophys Res Commun 445:170-174, 2014
4) Sun H, Niisato N, Nishio K, Hamilton KL, Marunaka Y
Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl– secretion: useful tools as regulators of Cl– secretion
BioMed Res Int 2014:902735, 2014
5) Shiozaki A, Nako Y, Ichikawa D, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E
Role of the Na+/K+/2Cl– cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma
World Journal of Gastroenterology 20:6844-59, 2014
6) Shiozaki A, Ichikawa D, Takemoto K, Nako Y, Nakashima S, Shimizu H, Kitagawa M, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E
Efficacy of a hypotonic treatment for peritoneal dissemination from gastric cancer cells-An in vivo evaluation
BioMed Res Int 2014:707089, 2014
7) Shiozaki A, Takemoto K, Ichikawa D, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E
The K-Cl cotransporter KCC3 as an independent prognostic factor in human esophageal squamous cell carcinoma
BioMed Res Int 2014:936401, 2014
8) Yuan Y, Wang X, Lu X, MARUNAKA Y, Wang X
Effect of Coptidis Rhizoma extracts in a water-based solution on insulin resistance in 3T3-L1 adipocytes
Biomed Res 35:321-327, 2014
9) Sun H, Niisato N, Inui T, MARUNAKA Y
Insulin is involved in transcriptional regulation of NKCC and CFTR Cl– channel through PI3K activation and ERK inactivation in renal epithelial cells
J Physiol Sci 64:433-443, 2014
10) Tanaka S, Sugiyama N, Takahashi Y, Mantoku D, Sawabe Y, Kuwabara H, Nakano T, Shimamoto C, Matsumura H, Marunaka Y, Nakahari T
PPARα autocrine regulation of Ca2+-regulated exocytosis in guinea pig antral mucous cells: NO and cGMP accumulation.
Am J Physiol Gastrointest Liver Physiol 307:G1169-1179, 2014
国際学会
特別講演、招聘講演、基調講演、教育講演など
1) Niisato N, Marunaka Y. Regulation of epithelial Na+ channel (ENaC) trafficking by aldosterone. International Symposium on Renal Physiology Chinese Society of Physiology. 2014.10.25-27; Shanghai, China
国際学会
シンポジウム、ワークショップ、パネルディスカッションなど
1) Nomura T. The Effects of Lipid Environment on the Mechanosensitivity of Bacterial Mechanosensitive Channel. Mechanosensory Transduction Symposium, 2014.8.2; Gold Coast, Australia.
2) Taruno A, J. Kevin Foskett , Marunaka Y. Calcium homeostasis modulator(CALHM) ion channel family encoding voltage-gated ATP release ion channels involved in non-synaptic purinergic neurotransmission. The 37th Annual Meeting of the Japan Neuroscience Society. 2014.9.11-13；Yokohama
3) Niisato N, Marunaka Y. A role of p38 on proteasome-dependent degradation of ENaC in aldosterone-stimulated renal epithelial A6 cells. The 2nd International Symposium on Epithelial Barrier and Transport. 2014.11.1-2；Shiga
国際学会
一般講演（ポスター含む）
1) Miyazaki H, Tanaka S, Marunaka Y. Oscillatory changes in the intracellular concentration of Cl– control cell cycle progression via changes in the activity of Na+-K+-2 Cl– cotransporter in MKN28 gastric cancer cells. The 2nd International Symposium on Epithelial Barrier and Transport. 2014.11.1-2；Shiga
2) Taruno A, Marynaka Y, J. Kevin Foskett . Identification of a novel ATP release ion channel, CALHM1, essentially required for purinergic neurotransmission of tastes. The 2nd International Symposium on Epithelial Barrier and Transport. 2014.11.1-2；Shiga
3) Nomura T,Taruno A, Nakahari T,Sokabe M, Marunaka Y. Single-channel gating kinetic analysis of mouse pannexin 1 channel. 2 The 2nd International Symposium on Epithelial Barrier and Transport. 2014.11.1-2；Shiga
4) Sun Hongxin, Niisato N, Marunaka Y. Involvement of insulin in transcriptional regulation of NKCC and CFTR Cl– channel through PI3K activation and ERK inactivation in renal epithelial A6 cells. The 2nd International Symposium on Epithelial Barrier and Transport. 2014.11.1-2；Shiga
5) Hayata H, Miyazaki H, Niisato N, Yokoyama N, Marunaka Y. Lowered extracellular pH induces the pathogenesis of insulin resistance in skeletal muscle. The 2nd International Symposium on Epithelial Barrier and Transport. 2014.11.1-2；Shiga
国内学会
シンポジウム、ワークショップ、パネルディスカッションなど
1) Marunaka Y, Niisato N, Yokoyama N, Sasamoto K
Molecular mechanisms of regulation of ENaC expression and intracellular
trafficking in renal epithelium
Symposium on “Metabolic regulation of renal physiology and pathophysiology”
FAOPS Joint Symposium-Japan/China
The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
2) Niisato N, Marunaka Y
An essential role of p38 on ENaC trafficking in aldosterone-stimulated Na+ reabsorption in renal epithelial A6 cells.
Symposium on “New aspects of molecular mechanisms of ENaC-mediated Na+ homeostasis and body fluid regulation”
The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
3) Taruno A, Marunaka Y, Foskett J Kevin
Calcium Homeostasis Modulator (CALHM): A novel ion channel family encoding voltage-gated ATP release ion channels involved in non-synaptic neurotransmission from taste cells.
Symposium on“Cutting-edge researches of membrane proteins−Towards molecular mechanisms and physiological functions”
The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
4) Yokoyama N, Marunaka Y
Molecular mechanism of regulation of epithelial Na+ channel (ENaC) activity at the plasma membrane – Roles of raft domain.
Symposium on “New aspects of the hierarchical study on function and morphology of epithelial membrane”
Collaboration Symposium with The Membrane Society of Japan
The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
5) Niisato N, Marunaka Y.
Molecular mechamims of Epithelial Na+channel (ENaC) regulation. Symposium on “Epithelial Ion Transport”
The 134th Annual Meeting of The Pharmaceutical Society of Japan.
2014.3.27-30, Kumamoto
6) 笹本 浩平、新里 直美、丸中 良典. 上皮組織における電気的中性クロライドイオン輸送体活性の電気生理学的機能測定の可能性：数理モデル活用による測定法の新展開. 第9回京滋呼吸器リサーチフォーラム. 2014.4.5 ; 京都
7) 丸中 良典、笹本 浩平、新里 直美. 上皮組織クロライドイオン分泌に寄与する電気的中性クロライドイオン輸送体活性の電気生理学的測定の新展開：数学的シミュレーション活用による新測定法の確立. 第13回肺サーファクタント分子病態研究会. 2014.6.21 ; 札幌
8) 小木曾 遥香、中張 隆司.β2刺激時マウス末梢気道線毛運動周波数のCa2+依存性PDE1による調節. 第13回肺サーファクタント分子病態研究会. 2014.6.21 ; 札幌
9) 樽野 陽幸，Zhong ming Ma，新里 直美，宮崎 裕明，加塩 麻紀子，孫 紅昕，Foskett J Kevin，丸中 良典. CALHMイオンチャネルの構造・機能の解析. 膜シンポジウム 2014. 2014.11.26-27 ; 神戸
国内学会
一般講演（ポスター含む）
1) Miyazaki H, Marunaka Y
Regulatory mechanisms of the G1 to S phase cell cycle progression via changes in the intracellular concentration of Cl- in MKN28 human gastric cancer cells.
The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
2) Hosogi S, Marunaka Y, Niisato N, Kusuzaki K, Miyazaki H
Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell. The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
3) Hayata H, Miyazaki H, Niisato N, Yokoyama N, Marunaka Y
Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance.
The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
4) Sun Hongxin, Niisato N, Marunaka Y
Quercetin diminishes the cAMP-stimulated Cl– secretion by blocking Na+, K+ -ATPase in epithelial cells.
The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
5) Sasamoto K, Niisato N, Marunaka Y
Estimation of activity of electro-neutral ion transporter by establishing mathematical model of Cl– secretion in epithelial cells based on measurement of transcellular ion transport and membrane ion conductance.
The 91st Annual Meeting of the Physiological Society of Japan. 2014.3.16-18; Kagoshima
6) 丸中 良典、笹本 浩平、新里 直美、西尾 恭介.
腎上皮細胞クロライドイオン輸送にかかわる電気的中性イオン輸送体活性の電気生理学的手法による検証.
第57回日本腎臓学会学術総会. 2014.7.4-6 ; 横浜
7) 新里 直美、西尾 恭介、丸中 良典.
アルドステロンによるp38を介するNa+ 再吸収亢進における細胞内クロライドイオンの役割解明.
第57回日本腎臓学会学術総会. 2014.7.4-6 ; 横浜
8) 笹本 浩平、新里 直美、丸中 良典.
上皮組織クロライドイオン分泌に寄与する電気的中性クロライドイオン輸送体活性の電気生理学的測定の新展開.
第107回近畿生理談話会. 2014.10.25 ; 神戸
9) Sun Hongxin, Niisato N, Marunaka Y.
Transcriptional regulation of NKCC and CFTR Cl- channel through PI3K activation and ERK inactivation by insulin in renal epithelial A6 cells.
第107回近畿生理談話会. 2014.10.25 ; 神戸
10) 野村 健、樽野 陽幸、中張 隆司、曽我部 正博、丸中 良典.
Pannexin 1 の単一イオンチャネルゲーティングキネティクスの膜電位依存性.
第107回近畿生理談話会. 2014.10.25 ; 神戸
11) 田中 早織、中張 隆司.
胃幽門腺粘液細胞Ca2+調節性開口放出に対するインドメタシン（IDM）の効果.
第107回近畿生理談話会. 2014.10.25 ; 神戸
12) 樽野 陽幸，J. Kevin Foskett，丸中 良典.
味覚神経伝達を担う新規ATP放出イオンチャネルCALHM1の同定.
生理学研究所研究会. 2014.10.28 ; 岡崎
13) 野村 健、樽野 陽幸、中張 隆司、曽我部 正博、丸中 良典.
Pannexin 1の単一イオンチャネルゲーティングキネティクス解析
粘膜免疫学と膜輸送生理学の融合.
生理学研究所研究会. 2014.10.28 ; 岡崎
学術集会でのプロシーディングス
1) Marunaka Y, Niisato N, Yokoyama N, Sasamoto K
Molecular mechanisms of regulation of ENaC expression and intracellular
trafficking in renal epithelium
J Physiol Sci. 64 (Suppl-1): 50, 2014.
2) Niisato N, Marunaka Y
An essential role of p38 on ENaC trafficking in aldosterone-stimulated Na+ reabsorption in renal epithelial A6 cells.
J Physiol Sci. 64 (Suppl-1): 27, 2014.
3) Taruno A, Marunaka Y, Foskett J Kevin
Calcium Homeostasis Modulator (CALHM): A novel ion channel family encoding voltage-gated ATP release ion channels involved in non-synaptic neurotransmission from taste cells.
J Physiol Sci. 64 (Suppl-1): 85, 2014.
4) Yokoyama N, Marunaka Y
Molecular mechanism of regulation of epithelial Na+ channel (ENaC) activity at the plasma membrane – Roles of raft domain.
J Physiol Sci. 64 (Suppl-1): 40, 2014.
5) Miyazaki H, Marunaka Y
Regulatory mechanisms of the G1 to S phase cell cycle progression via changes in the intracellular concentration of Cl– in MKN28 human gastric cancer cells.
J Physiol Sci. 64(Suppl-1): 267, 2014.
6) Hosogi S, Marunaka Y, Niisato N, Kusuzaki K, Miyazaki H
Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell.
J Physiol Sci. 64 (Suppl-1): 215, 2014.
7) Hayata H, Miyazaki H, Niisato N, Yokoyama N, Marunaka Y
Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance.
J Physiol Sci. 64 (Suppl-1): 275, 2014.
8) Sun Hongxin, Niisato N, Marunaka Y
Quercetin diminishes the cAMP-stimulated Cl– secretion by blocking Na+, K+ -ATPase in epithelial cells.
J Physiol Sci. 64 (Suppl-1): 116, 2014.
9) Sasamoto K, Niisato N, Marunaka Y
Estimation of activity of electro-neutral ion transporter by establishing mathematical model of Cl– secretion in epithelial cells based on measurement of transcellular ion transport and membrane ion conductance.
J Physiol Sci. 64 (Suppl-1): 227, 2014.
科研費
1）丸中良典（研究代表者）：挑戦的萌芽研究 (継続、H25～H26) 「ISFETpHセンサーを用いた間質液pH連続測定とインスリン抵抗性発症機構解明」
2）新里直美（研究代表者）：基盤研究（C）（一般）（継続、H24～H26）「ENaC制御因子を分子標的としたフラボノイドによる食塩感受性高血圧抑制機構の解明」
3）宮崎裕明（研究代表者）：基盤研究（C）（一般）（継続、H25～H27）「WNKキナーゼによるCl- 輸送体活性制御破綻が引き起こす癌転移メカニズムの解明」
4）樽野陽幸（研究代表者）：若手（A）（新規:H26～H28年度）「味覚情報の抽出・処理・統合機構の解析」
5）中島謙一（研究代表者）：基盤研究（C）（一般）（継続、H24～H26）「クロライドイオンによる低分子量Gタンパク質活性制御を介した神経細胞死の抑制」（但し渡米により辞退）
6）細木誠之（研究代表者）：基盤研究（C）（一般）（新規、H26～H28）「癌幹細胞特異的プロトン制御機構を分子標的とした新たな癌治療戦略の展開」
7）野村健（研究代表者）：基盤研究（C）（一般）（新規、H26～H28）「パッチフルオロメトリー法を用いた機械刺激によるパネキシン1の活性化機構の解析」
民間研究財団
1) 樽野陽幸（研究代表者） ソルトサイエンス研究財団 平成26年度研究助成
「ENaC発現味蕾細胞の塩味センサー機構の解明」
受賞
樽野陽幸
「日本生理学会：入澤宏・彩記念若手研究奨励賞／イオンチャネル・トランスポーター分野」
(Irisawa Memorial Promotion Award for Young Physiologists, 2014)
「末梢味覚神経伝達のイオンチャネルメディエータCALHM1の同定」
細木誠之
第91回日本生理学会大会「優秀ポスター賞」
笹本浩平
第91回日本生理学会大会「優秀ポスター賞」
