和文総説
1) 小木曽遥香、池内優紀子、細木誠之、田中早織、島本史夫、中張隆司、丸中良典．
マウス末梢気道線毛運動周波数のcAMP調節：Ca2+依存性PDE1Aの役割．
分子呼吸器病 21: 94-97, 2017
2) 樽野陽幸
甘味受容の仕組みと人工甘味料
食と医療 2017SUMMER-FALL Vol.2 , 2017.7
和文その他
1）丸中良典
特別座談会：フレイルと人参養栄湯〜健康長寿に向けて〜
出席者）乾明夫、武田宏司、寺山靖夫、矢田俊彦、上園保仁、相良博典、櫻井孝、大澤匡弘、丸中良典、加島雅之、森永明倫、高橋隆二
phil漢方 65, 2017.7
英文総説
1) Marunaka Y
Actions of quercetin, a flavonoid, on ion transporters: its physiological roles
Annals of the New York Academy of Sciences 2017 1398(1):142-151, 2017.
2) Shiozaki A, Ichikawa D, Kosuga T, Marunaka Y, Otsuji E.
Regulation of osmolality for cancer treatment.
J Physiol Sci 67(3):353-360, 2017.
3) Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A.
Actions of quercetin, a polyphenol, on blood Pressure.
Molecules 22(2). pii: E209, 2017.
4）MARUNAKA Y.
The mechanistic links between insulin and cystic fibrosis transmembrane conductance regulator (CFTR) Cl– channel
Int J Mol Sci 18(8):1767, 2017
原著
1) Puppulin P, Pezzotti G, Sun H, Hosogi S, Nakahari T, Inui T, Kumamoto Y, Tanaka H, Marunaka Y
Raman micro-spectroscopy as a viable tool to monitor and estimate the ionic transport in epithelial cells
Scientific Reports 7(1):3395, 2017.
2) Kogiso H, Hosogi S, Ikeuchi Y, Tanaka S, Shimamoto C, Matsumura H, Nakano T, Sano K, Inui T, Marunaka Y, Nakahari T
A low [Ca2+]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia
Pflügers Archiv – Eur J Physiol 2017. doi: 10.1007/s00424-017-1988-9 [Epub ahead of print]
3) Tanaka S, Miyazaki H, Shioazaki A, Ichikawa D, Otsuji E, Marunaka Y.
Cytosolic Cl– affects the anticancer activity of paclitaxel in the gastric cancer cell line, MKN28 cell.
Cell Physiol Biochem 42:68-80, 2017
4) Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, , Marunaka Y, Otsuji E.
Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor.
J Gastroenterol 2017. doi: 10.1007/s00535-017-1338-x. [Epub ahead of print]
5) Sasamoto K, Marunaka R, Niisato N, Sun H, Taruno A, Pezzottia G, Yamamoto T, Kanamura N, Zhu W, Nishio K, Inui T, Eaton DC, Marunaka Y
Analysis of aprotinin, a protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model
Cell Physiol Biochem 41:1865-1880, 2017
6) Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
Heat shock exerts anticancer effects on liver cancer via autophagic degradation of aquaporin
Int J Oncol 50(5):1857-1867, 2017.
7) Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.
Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma
Oncotarget 8(11):17921-17935, 2017
8) Taruno A, Marunaka Y.
Hypotonicity activates a voltage-dependent membrane conductance in N2a neuroblastoma cells.
Biochem Biophys Res Commun 484(2):331-335, 2017.
9) Taruno A, Kashio M, Sun H, Kobayashi K, Sano H, Nambu A, Marunaka Y
Adeno-associated virus-mediated gene transfer into taste cells in vivo
Chemical Senses 42(1):69-78, 2017 (selected for journal cover page)
10) Yoshimoto K, Nagao M, Watanabe Y, Yamaguchi T, Ueda S, Kitamura Y, Nishimura K, Inden M, Marunaka Y, Hattori H, Murakami K, Tokaji M, Ochi K.
Enhanced alcohol-drinking behavior associated with active ghrelinergic and serotoninergic
neurons in the lateral hypothalamus and amygdala.
Pharmacol Biochem Behavior 153:1-11, 2017
11) Ariyoshi Y, Shiozaki A, Ichikawa D, Shimizu H, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.
Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma.
Oncotarget 8(2):2209-2223, 2017
12) Pezzotti G, Adachi T, Gasparutti I, Vincini G, Zhu W, Boffelli M, Rondinella A, Marin E, Ichioka H, Yamamoto T, Marunaka Y, Kanamura N
Vibrational monitor of early demineralization in tooth enamel after in vitro exposure to phosphoridic liquid
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 173:19-33, 2017
13) Taruno A, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y
Post-translational palmitoylation controls the voltage gating and lipid raft association of CALHM1 channel
J Physiol (London) 595(18):6121-6145, 2017
14) Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi K, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, Marunaka Y, Otsuji E.
Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer
Oncotarget (in press)
15) Nomura T, Taruno A, Shiraishi M, Nakahari T, Inui T, Sokabe M, Eaton DC, Marunaka Y.
Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics
Scientific Reports Sep 5;7(1):10512, 2017
16) Kogiso H, Hosogi S, Ikeuchi Y, Tanaka S, Inui T, Marunaka Y, Nakahari T.
[Ca2+]i modulation of cAMP-stimulated ciliary beat frequency via PDE1 in airway ciliary cells of mice.
Experimental Physiology (in press)
17) Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi M, Cui W, Matsuno K, Marunaka Y, Itoh Y, Torok NJ, Yabe-Nishimura C.
The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.
Free Radic Biol Med 2017 (in press)
国際学会 特別講演、招聘講演、基調講演、教育講演、シンポジウムなど
1）Marunaka Y. （基調講演）
Flavonoid action on ion transporters and channels: its physiological roles.
Phytochemical Society of Europe meeting 2nd International Symposium on Phytochemicals in Medicine and Food 2017.4.7-10; Fuzhou, China
2）Taruno A. (シンポジウム)
CALHM channel-mediated neurotransmission of tastes
Australasian Association for ChemoSensory Science (AACSS) 2017 2017.12.6-8; Hamilton Island, Australia
一般講演（ポスター含む）
1) Hosogi S, Nakahari T, Marunaka Y.
Ambroxol-Stimulated Increases in CBA and CBF Via pHi Increase and [Cl-]i Decrease in Airway Ciliary Cells of Mice
American thoracic society 2017 international conference, 2017.5.19-24; Washington, D.C., USA
2) Hosogi S.
Ambroxol-stimulated increases in CBA and CBF via pHi increase and [Cl-]i decrease in airway ciliary cells of mice.
Dynein 2017 International Workshop 2017.10.29-11.1; Awaji, Japan
国内学会 特別講演
1）Marunaka Y.
Regulation of body environments by epithelial ion transport
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
国内学会シンポジウム、ワークショップ、パネルディスカッションなど
1) 小木曽遥香、池内優紀子、細木 誠之、田中早織、中張隆司、丸中良典.
マウス末梢気道線毛運動の清肺湯(TJ-90)による活性化機構.
第12回京滋呼吸器リサーチフォーラム 2017.3.11; 京都
2) 澤祥幸、吉田勉、石黒崇、堀場あかね、二村洋平、深川富法、武藤敏弘、法雲智美、米田千枝、木下聖次郎、池内優紀子、細木 誠之、中張隆司.
気管支鏡検体を用いたLAMA/LABA配合剤の線毛機能に及ぼす効果評価の試み.
第12回京滋呼吸器リサーチフォーラム 2017.3.11; 京都
3) Taruno A, Marunaka Y
Neurotransmission of taste mediated by calcium homeostasis modulator ion channels
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
4) 細木誠之
細胞内pHとCl–を介した気道線毛運動活性化機構：Ambroxolの効果.
第40回日本呼吸器内視鏡学会学術集会 2017.6.9-10; 長崎
国内学会 一般講演（ポスター含む）
1) Kuwahara A, Kuwahara Y, Kato I, Karaki S, Ishizuka N, Hayashi H, Marunaka Y
Characterization of the biological activity of xenin fragments on spontaneous circular muscle contraction in rat distal colon
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
2) Miyazaki H, Marunaka Y
The molecular mechanism of Cl– regulating S-phase cell cycle transition via regulating DNA polymerase activity
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
3) Hosogi S, Murakami K, Kuremoto T, Yasuda M, Nakahari T, Hirano S, Marunaka Y
Epithelial ion secretion of human nasal ciliary epithelium
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
4) Kashio M, Taruno A, Marunaka Y
Molecular basis of polarized sorting of CALHM channels in epithelial cells
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
5) Nakajima K, Marunaka Y
Intracellular chloride ion concentration in growing neurite and its role in neurite outgrowth
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
6) Sun H, Taruno A, Nakajo K, Ono F, Marunaka Y
Palmitoylation regulates gating and lipid raft association of CALHM1 channel
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
7) Puppulin L, Pezzotti G, Sun H, Hosogi S, Nakahari T, Kumamoto Y, Tanaka H, Marunaka Y
Raman spectroscopy as a viable tool to monitor the effect of aldosterone on A6 renal epithelial cell
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
8) Tanaka S, Miyazaki H, Shiozaki A, Otsuji E, Marunaka Y
Cytosolic Cl– affects the anticancer activity of paclitaxel by influencing microtubule dynamics in the gastric cancer cell line, MKN28 cell
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
9) Kogiso H, Ikeuchi Y, Hosogi S, Tanaka S, Shimamoto C, Nakahari T, Marunaka Y
Ca2+-regulation of cAMP-activated ciliary beating mediated via PDE1 in mouse bronchiolar cilia
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
10) Ikeuchi Y, Kogiso H, Tanaka S, Hosogi S, Nakahari T, Marunaka Y
Carbocistein-activated bronchiolar ciliary beating via Cl–– and pHi-pathway in mice
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
11) Shiraishi M, Nomura T, Taruno A, Marunaka Y
Current-direction/amplitude-dependent single channel gating kinetics of Pannexin 1 channel
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
12) Tanaka S, Hosogi S, Shimamoto C, Matsumura H, Nakahari T, Marunaka Y
Production of arachidonic acid, a ligand for PPARα, activated by ACh in antral mucous cells
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
13) Sasamoto K, Niisato N, Marunaka Y
Aprotinin reduces the recycling rate of epithelial Na+ channels (ENaC) to the apical membrane of an epithelial cell: a four-state model of intracellular ENaC trafficking
The 94th Annual Meeting of the Physiological Society of Japan. 2017.3.28-30; Hamamatsu.
14) 澤祥幸、長谷川貴昭、二村洋平、堀場あかね、石黒崇、吉田勉、丸井努、細木誠之
気道支上皮線毛運動測定の中央化に向けて−細胞簡易保存の検討
第57回日本呼吸器学会学術講演会 2017.4.21-23 ; 東京
15) 小木曾遥香、池内優紀子、角谷昌子、細木誠之、中張隆司、丸中良典.
清肺湯による気道線毛運動活性化機構.
第16回肺サーファクタント分子病態研究会. 2017.6.3; 札幌
16) 澤 祥幸、二村洋平、堀場あかね、石黒 崇、吉田 勉、丸井 努、細木誠之
基礎研究施設と連携した下気道気管支上皮線毛機能測定の新規中央検査化の検討.
第40回日本呼吸器内視鏡学会学術集会 2017.6.9-10; 長崎
17）宮崎裕明、田中幸恵、丸中良典．
細胞内クロライドイオンがpaclitaxelの増殖抑制効果に及ぼす影響
2017年度生理学研究所研究会.『体内環境の維持機構における上皮輸送の多角的・統合的理解』2017.9.7-8 ; 岡崎
18) 樽野陽幸、孫 紅昕 、中條浩一、村上達郎、大崎康吉、城戸瑞穂、小野富三人、丸中良典.
パルミトイル化がCALHM1チャネルのゲーティングと脂質ラフト局在を制御する
日本味と匂学会第51回大会. 2017.9.25-27；神戸
19) 池内優紀子、小木曾遥香、細木誠之、田中早織、中張隆司、丸中良典
マウス気道線毛細胞におけるカルボシステインによる Cl–を介した CBA の調節
第110回近畿生理談話会. 2017.11.18 ; 神戸
20) 乾 隆昭、村上賢太郎、細木誠之、中張 隆司、安田 誠、平野 滋、丸中良典
細胞内 Cl–濃度依存的ヒト鼻粘膜線毛運動
第110回近畿生理談話会. 2017.11.18 ; 神戸
21) 小木曾遥香、池内優紀子、細木誠之、田中早織、Raveau M、山川和弘、 中張隆司、丸中良典
ダウン症モデルマウスの末梢気道線毛運動周波数における PDE1 活性の亢進
第110回近畿生理談話会. 2017.11.18 ; 神戸
22) Okui M, Sun H, Taruno A, Marunaka Y.
Palmitoylation of CALHM3 positively controls activity of the CALHM1/3 channel
第110回近畿生理談話会. 2017.11.18 ; 神戸
23) Puppulin L, Sun H, Marunaka Y.
The cytosolic ionic concentration gradients in the cytosolic space of aldosterone-treated renal epithelial cells detected by Raman Spectroscopy
第110回近畿生理談話会. 2017.11.18 ; 神戸
学術集会でのプロシーディングス
1) Marunaka Y.
Regulation of body environments by epithelial ion transport
J Physiol Sci. 67 (suppl-1): 6, 2017.
2) Taruno A, Marunaka Y
Neurotransmission of taste mediated by calcium homeostasis modulator ion channels
J Physiol Sci. 67 (suppl-1): 15, 2017.
3)Kuwahara A, Kuwahara Y, Kato I, Karaki S, Ishizuka N, Hayashi H, Marunaka Y
Characterization of the biological activity of xenin fragments on spontaneous circular muscle contraction in rat distal colon
J Physiol Sci. 67 (suppl-1): 101, 2017.
4) Miyazaki H, Marunaka Y
The molecular mechanism of Cl– regulating S-phase cell cycle transition via regulating DNA polymerase activity
J Physiol Sci. 67 (suppl-1): 179, 2017.
5) Hosogi S, Murakami K, Kuremoto T, Yasuda M, Nakahari T, Hirano S, Marunaka Y
Epithelial ion secretion of human nasal ciliary epithelium
J Physiol Sci. 67 (suppl-1): 103, 2017.
6) Kashio M, Taruno A, Marunaka Y
Molecular basis of polarized sorting of CALHM channels in epithelial cells
J Physiol Sci. 67 (suppl-1): 153, 2017.
7) Nakajima K, Marunaka Y
Intracellular chloride ion concentration in growing neurite and its role in neurite outgrowth
J Physiol Sci. 67 (suppl-1): 142, 2017.
8) Sun H, Taruno A, Nakajo K, Ono F, Marunaka Y
Palmitoylation regulates gating and lipid raft association of CALHM1 channel
J Physiol Sci. 67 (suppl-1): 153, 2017.
9) Puppulin L, Pezzotti G, Sun H, Hosogi S, Nakahari T, Kumamoto Y, Tanaka H, Marunaka Y
Raman spectroscopy as a viable tool to monitor the effect of aldosterone on A6 renal epithelial cell
J Physiol Sci. 67 (suppl-1): 154, 2017.
10) Tanaka S, Miyazaki H, Shiozaki A, Otsuji E, Marunaka Y
Cytosolic Cl- affects the anticancer activity of paclitaxel by influencing microtubule dynamics in the gastric cancer cell line, MKN28 cell
J Physiol Sci. 67 (suppl-1): 177, 2017.
11) Kogiso H, Ikeuchi Y, Hosogi S, Tanaka S, Shimamoto C, Nakahari T, Marunaka Y
Ca2+-regulation of cAMP-activated ciliary beating mediated via PDE1 in mouse bronchiolar cilia
J Physiol Sci. 67 (suppl-1): 176, 2017.
12) Ikeuchi Y, Kogiso H, Tanaka S, Hosogi S, Nakahari T, Marunaka Y
Carbocistein-activated bronchiolar ciliary beating via Cl– and pHi-pathway in mice
J Physiol Sci. 67 (suppl-1): 137, 2017.
13) Shiraishi M, Nomura T, Taruno A, Marunaka Y
Current-direction/amplitude-dependent single channel gating kinetics of Pannexin 1 channel
J Physiol Sci. 67 (suppl-1): 153, 2017.
14)Tanaka S, Hosogi S, Shimamoto C, Matsumura H, Nakahari T, Marunaka Y
Production of arachidonic acid, a ligand for PPARα, activated by ACh in antral mucous cells
J Physiol Sci. 67 (suppl-1): 174, 2017.
15) Sasamoto K, Niisato N, Marunaka Y
Aprotinin reduces the recycling rate of epithelial Na+ channels (ENaC) to the apical membrane of an epithelial cell: a four-state model of intracellular ENaC trafficking
J Physiol Sci. 67 (suppl-1): 84, 2017.
16) 澤祥幸、長谷川貴昭、二村洋平、堀場あかね、石黒崇、吉田勉、丸井努、細木誠之
気道支上皮線毛運動測定の中央化に向けて−細胞簡易保存の検討
日本呼吸器学会誌 Vol.6 増刊号: 300, 2017
科研費
1) 桑原厚和（研究代表者） 基盤研究（C) （継続、H27~29)「消化管粘膜上皮における
化学物質受容機構に関する研究」
2）宮崎裕明（研究代表者）：基盤研究（C）（一般）継続、H28～H30）「「癌細胞のクロライドシフト」による細胞接着能変化を介した癌転移メカニズムの解明」
3) 樽野陽幸（研究代表者）：挑戦的萌芽研究 (継続、H28～H30)「CALHMチャネル機能を基盤とした感覚情報伝達機構の新規概念の構築」
4）細木誠之（研究代表者）：基盤研究（C）（一般）（新規、H29～H31）「COPDにおけるイオン輸送体を分子標的とした気道粘液線毛輸送系活性化療法の開発」
5) 孫 紅昕 （研究代表者）：若手研究（B）（一般）(継続、H28～H30) 「味蕾における塩味コーディング様式の解明」
6) プップリン レオナルド（研究代表者）：若手研究（B）（一般）
(継続、H28～H30) 「光学的方法を用いた組織間質液イオン環境の非侵襲的測定法開発」
7） 新里直美（研究代表者）：基盤研究（C）（一般）継続、H27～H29）「形質膜タンパク質のプロテアソームへの新規ターゲティング機構の解明」
民間研究財団
1）樽野陽幸（研究代表者）：うま味研究会 研究助成「細胞種特異的味細胞活動記録法による味覚コーディング様式の解明」
受賞
1) 樽野陽幸：安藤百福賞 発明発見奨励賞「甘味・旨味・苦味に関わる味覚神経伝達の分子機構の解明」
